Publications by authors named "R A Cairns"
Article Synopsis
- Self-poisoning is the most common form of self-harm among young people in Australia, and rates have been increasing, especially during and after the COVID-19 pandemic.
- A study analyzed data from poison information centers from 2018 to 2023, finding a significant rise in self-poisoning cases, particularly among females aged 5-19, with an overall increase of 29.6% during this period.
- After pandemic restrictions lifted, there was an initial drop in self-poisoning cases, but they declined slowly overall, highlighting the need for ongoing monitoring and support for mental health among young people.
2-Aminoethanethiol dioxygenase (ADO) is a thiol dioxygenase that sulfinylates cysteamine and amino-terminal cysteines in polypeptides. The pathophysiological roles of ADO remain largely unknown. Here, we demonstrate that ADO expression represents a vulnerability in cancer cells, as ADO depletion led to loss of proliferative capacity and survival in cancer cells and reduced xenograft growth.
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- The study highlights the growing issue of poisoning in New South Wales, Australia, indicating a need for better data on its impact on health outcomes and its epidemiology.
- It analyzed a decade's worth of health data (2011-2020) from various sources, revealing over 845,000 events related to poisoning, with the majority stemming from adverse drug reactions and intentional poisonings, particularly affecting younger individuals.
- The findings show that demographics and reasons for poisoning vary significantly, with notable contributions from substance and mood disorders, suggesting a complex interplay between mental health and poisoning cases in the region.