Thermodynamics and kinetics of joint action of antiviral agent tilorone and DMSO on model lipid membranes.

Individual and joint action of two water-soluble drugs, DMSO and tilorone, on model l-α-dipalmitoylphosphatidylcholine (DPPC) membranes were studied in equilibrium and kinetic regimes by differential scanning calorimetry (DSC). For equilibrium experiments, the drugs were introduced during preparation of the model membrane. In kinetic studies, one of the drugs was added to the DPPC membrane already containing the other drug, and the effects of drug-membrane interactions were monitored in real-time regime.

Modification of delayed radiation-induced reactions of duodenal vessels and mast cells in old rats.

Pronounced ultrastructural changes in vessels and mast cells were observed in duodenal lamina propria of Wistar rats 1 year after single whole-body gamma-irradiation in a dose of 7.5 Gy. Inhibition of adrenocortical function with methopyrone reduced structural damage and improved animal survival.

[The behavior of 125I microspheres of serum albumin in the body of rabbits administered the preparation selectively into the renal artery].

Intraarterial selective injection of serum albumin microspheres into the kidney resulted in embolization of the vessels with microspheres of different sizes. In vivo radiometry made it possible to improve the localization of microspheres and their distribution in the animals' bodies at varying time of observation. Pathomorphological investigations showed optimum sizes of microspheres causing prolonged retention of microparticles at the site of injection without considerable morphological changes of body tissues.

[The effect of chronic butyphos poisoning on protein and nucleic acid synthesis in various rat organs and activity of blood cholinesterase].

Two doses of butyphos (1/10 and 1/50 LD50) were administered into rats within 6 months. Content of DNA was distinctly decreased in liver and kidney tissues within the first 2 weeks of the pesticide administration. Then DNA synthesis was increased 2-fold in liver tissue and remained high during all the 6 months of intoxication.

[Ultrastructure of the vessels of the submucosal membrane of the rat small intestine at long intervals following fractionated irradiation].

The time course of ultrastructural changes in the walls of arterial type vessels was studied in the small intestinal submucous membrane of Wistar male rats long after fractionated irradiation of the abdominal area. Three phases were identified in the development of vascular response to irradiation; mechanisms of their development are under discussion.