Publications by authors named "R A Bright"
As transplant programmes have evolved to allow a wider donor pool, organ acceptance decisions have become increasingly complex and lack transparency and equality. Clinical scoring tools exist but there is limited consensus on their use. From a prospective observation of consecutive deceased-donor kidney offers in a large urban transplant centre, a simple score was developed based on donor age and other risk characteristics, excluding ischemia time and graft histology.
View Article and Find Full Text PDFChronic and recurring wounds pose a significant challenge in modern healthcare, leading to substantial morbidity. These wounds allow pathogens to colonize, potentially resulting in local and systemic infections. Current interventions need to be revised and become increasingly less reliable due to the emergence of antibiotic resistance.
View Article and Find Full Text PDFArticle Synopsis
- The increasing ageing population necessitates better orthopedic implants to address issues like infection and inflammation affecting implant longevity.
- Researchers explored bioinspired nanostructured materials, specifically titanium alloy and plasma-sprayed titania, to enhance antibacterial properties and blood compatibility in complex environments.
- The study found that these nanostructured surfaces exhibited strong antibacterial effects and improved platelet healing responses compared to traditional materials, suggesting their potential in orthopedic applications.
Focused Ultrasound in Cancer Immunotherapy: A Review of Mechanisms and Applications.
Ultrasound Med Biol
January 2025
Article Synopsis
- Ultrasound, particularly focused ultrasound (FUS), is recognized not only for its diagnostic capabilities but also for its therapeutic functions in cancer treatment, including tissue ablation.
- * Cancer immunotherapy, a rising approach that enhances the immune system to combat cancer, is considered one of the four main cancer treatments due to its reduced side effects compared to traditional methods.
- * The review discusses the emerging field of FUS-induced/assisted cancer immunotherapy, exploring its mechanisms, current applications, and both preclinical and clinical studies to support its development and medical expansion.*