Subtle CXCR3-Dependent Chemotaxis of CTLs within Infected Tissue Allows Efficient Target Localization.

It is well established how effector T cells exit the vasculature to enter the peripheral tissues in which an infection is ongoing. However, less is known regarding how CTLs migrate toward infected cells after entry into peripheral organs. Recently, it was shown that the chemokine receptor CXCR3 on T cells has an important role in their ability to localize infected cells and to control vaccinia virus infection.

Familial chronic central serous chorioretinopathy.

Twenty-seven patients with characteristic, mostly bilateral, fundus lesions of chronic central serous chorioretinopathy (CSC) and a progressive course, and 80 of their relatives, mainly siblings, were examined. Ophthalmologic examination included assessment of visual acuity, Amsler grid testing, ophthalmoscopy and fluorescein angiography. The fundus findings were classified as normal fundus, multiple areas of retinal pigment epithelium (RPE) atrophy or chronic CSC: RPE atrophy with leakage of fluorescein.

The effect of high-intensity focused ultrasound on intraocular pressure in therapy-resistant glaucoma 3-4 months and 1 year after treatment.

The effect of therapeutic ultrasound for the treatment of refractory glaucoma was evaluated in 44 patients by comparing average IOP curves measured before and 3-4 months after treatment. The insonification regime was standardized and the glaucoma medication in each individual patient was unchanged during IOP curve measurements. The average IOP decrease 3-4 months after insonification was 42.

The effect of white light exposure on the rabbit eye lens as measured by fluorophotometry and spectrophotometry.

Fluorophotometry and spectrophotometry of the rabbit lens were performed after white light exposure to detect possible changes in the lens before damage could be seen by biomicroscopic slit lamp examination. In nine rabbits the lens of one eye was exposed to white light and that of the fellow eye was used as a control. The incident light power was 240 mW for 90 min on a lenticular area of 3 mm2.

Fluorophotometric assessment of blood-retinal barrier function after white light exposure in the rabbit eye.

Fluorophotometry was performed in 14 rabbits after exposure of one eye to white light with an energy insufficient to cause visible phototoxic retinal damage as determined by ophthalmoscopy and fundus photography. Fluorescence measurements in the vitreous were performed before and 1 hr after i.v.