Publications by authors named "R A Benn"
Functional connectivity holds promise as a biomarker of schizophrenia. Yet, the high dimensionality of predictive models trained on functional connectomes, combined with small sample sizes in clinical research, increases the risk of overfitting. Recently, low-dimensional representations of the connectome such as macroscale cortical gradients and gradient dispersion have been proposed, with studies noting consistent gradient and dispersion differences in psychiatric conditions.
View Article and Find Full Text PDFSensory information mainly travels along a hierarchy spanning unimodal to transmodal regions, forming multisensory integrative representations crucial for higher-order cognitive functions. Here, we develop an fMRI based two-dimensional framework to characterize sensory integration based on the anchoring role of the primary cortex in the organization of sensory processing. Sensory magnitude captures the percentage of variance explained by three primary sensory signals and decreases as the hierarchy ascends, exhibiting strong similarity to the known hierarchy and high stability across different conditions.
View Article and Find Full Text PDFArticle Synopsis
- A new method using diffusion MRI has allowed researchers to create white matter atlases from primate brains for comparative studies.
- The study produced the first white matter atlas of a lar gibbon, revealing similar temporal lobe specializations to those found in great apes, such as the expansion of certain brain tracts.
- These findings indicate that such white matter expansions may have originated in the common ancestor of hominoids around 16 million years ago and highlight the importance of white matter atlases in understanding brain evolution among primates.
Background: Knee osteoarthritis (OA) is a chronic, debilitating, musculoskeletal condition that affects millions. The increase in prevalence and its economic impact on healthcare and society raise the need for additional non-surgical interventions.
Objective: To assess the referral rates to secondary care consultation and clinical outcomes in patients with severe knee OA treated with a home-based, non-surgical intervention.