Publications by authors named "R A Beinart"

The association between anaerobic ciliates and methanogenic archaea has been recognized for over a century. Nevertheless, knowledge of these associations is limited to a few ciliate species, and so the identification of patterns of host-symbiont specificity has been largely speculative. In this study, we integrated microscopy and genetic identification to survey the methanogenic symbionts of 32 free-living anaerobic ciliate species, mainly from the order Metopida.

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  • The study focuses on the diagnostic process of Brugada syndrome (BrS) using ajmaline to expose the Type 1 Brugada pattern in patients, highlighting limited data on different populations.
  • It analyzed 260 patients (average age 43.4, mostly males) who underwent ajmaline tests, revealing a significant number with syncope history and family backgrounds of BrS or sudden cardiac death.
  • Results showed that less than half of the subjects met the current diagnostic criteria for BrS, but the overall rate of serious arrhythmia events was low over a median follow-up period of three years.
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  • * Analyzed outcomes between patients who received imaging and those who did not, finding no significant differences in complications, recurrence of atrial fibrillation, or re-hospitalization rates after one year.
  • * Despite longer procedure times for those who underwent imaging (90 minutes vs. 74.5 minutes), the study concludes that pre-procedural imaging does not impact the safety or efficacy of PVI in managing atrial fibrillation.
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Background And Aims: Emerging evidence suggests an arrhythmogenic effect of Anti-Ro/SSA (anti-Ro) and anti-La/SSB (anti-La) antibodies in adults, potentially involving a subclinical intracardiac inflammatory process. Despite the established association between inflammation and ischemic heart disease (IHD), it is noteworthy that as of now no study has delved into the potential link between these antibodies and IHD. This population-based study aimed to examine the association between anti-Ro/La seropositivity and IHD in the general adult population.

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Ciliates are a diverse group of protists known for their ability to establish various partnerships and thrive in a wide variety of oxygen-depleted environments. Most anaerobic ciliates harbor methanogens, one of the few known archaea living intracellularly. These methanogens increase the metabolic efficiency of host fermentation via syntrophic use of host end-product in methanogenesis.

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