Publications by authors named "R A Beckman"
Diverse polysaccharide production and biofilm formation abilities of clinical Klebsiella pneumoniae.
NPJ Biofilms Microbiomes
December 2024
Klebsiella pneumoniae infections have become a growing threat for human health. The lack of understanding of the relationship between antibiotic resistance, mucoviscosity, and biofilm formation impedes our abilities to effectively predict K. pneumoniae infection outcomes.
View Article and Find Full Text PDFArticle Synopsis
- Hyperbaric oxygen therapy (HBOT) is gaining attention as a treatment for neurological and psychological disorders by promoting brain recovery and neuroplasticity.
- It works through several cellular mechanisms, improving processes like mitochondrial function, neurogenesis, synaptogenesis, and reducing inflammation.
- Clinical benefits include better cognitive function, recovery from brain injuries, and symptom relief for PTSD and fibromyalgia, suggesting HBOT's potential in neuromodulation deserves more research.
Neutral evolution of rare cancer mutations in the computer and the clinic.
NPJ Syst Biol Appl
October 2024
A distinct model of neutral evolution of rare cancer mutations is described and contrasted with models relying on the infinite sites approximation (that a specific mutation arises in only one cell at any instant). An explosion of genetic diversity is predicted at clinical cell numbers and may explain the progressive refractoriness of cancers during a clinical course. The widely used infinite sites assumption may not be applicable for clinical cancers.
View Article and Find Full Text PDFinfections have become a growing threat for human health. The lack of understanding of the relationship between antibiotic resistance, mucoviscosity, and biofilm formation in clinical isolates impedes our abilities to effectively predict K. infection outcomes.
View Article and Find Full Text PDF