Publications by authors named "R A Bark"
Surgery is the first line of treatment in gingival cancers of the mandible, and bone resection is necessary in the majority of cases. In the less extensive surgical option, marginal mandibulectomy (MM), the mandibular base is preserved. In contrast, in a segmental mandibulectomy (SM) the mandible is divided and the continuity is not preserved.
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- OSCC recurrence and mortality rates remain high despite various treatments, highlighting the need for improved prognostic models and biomarkers, particularly focusing on tumor-draining lymph nodes (TDLNs) and T regulatory cells (Tregs).
- A study of 49 OSCC patients found that certain immune cell markers in TDLNs, like elevated FoxP3+CD4+ and TIGIT+CD8+ cells, were linked to worse disease-free survival, while high levels of CXCR5+CD4+ cells indicated better outcomes.
- The research suggests that the expression of immune checkpoints on T cells within TDLNs could serve as critical prognostic biomarkers, pointing towards the potential benefits of using neoadjuvant immunotherapy to enhance
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- Oral squamous cell carcinoma (OSCC) has a better survival rate when detected early, but prognosis worsens if it spreads to lymph nodes; identifying biomarkers for early detection could improve treatment strategies.
- The study analyzed dendritic cells and T-cells in tumor-draining lymph nodes from 12 OSCC patients and compared them to 9 benign cases, revealing that certain immune cells in TDLNs show immunosuppressive characteristics and are linked to metastasis.
- Findings suggest that high PD-L1 expression on dendritic cells in TDLNs may indicate metastatic risk and poorer outcomes, positioning PD-L1 as a potential predictive biomarker for OSCC prognosis.
Three ΔI=1 bands with the πg_{9/2}⊗νg_{9/2} configuration have been identified in _{35}^{74}Br_{39}. Angular distribution, linear polarization, and lifetime measurements were performed to determine the multipolarity, type, mixing ratio, and absolute transition probability of the transitions. By comparing these experimental observations with the corresponding fingerprints and the quantum particle rotor model calculations, the second and third lowest bands are, respectively, suggested as the chiral partner and one-phonon wobbling excitation built on the yrast band.
View Article and Find Full Text PDFBackground: Optimum management of the N0 neck is unresolved in parotid salivary gland cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis and its´ clinical use is increasing for head and neck tumors. The object of this study was to establish whether the technique is applicable to detect distribution of sentinel nodes for parotid tumors.
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