Publications by authors named "R A Axtell"
Introduction: Government and insurance sponsored exercise programs have demonstrated decreased hospitalizations, but it is unclear if this is the case for self-referred programs.
Methods: In this retrospective cohort study from 2013 to 2020, older adults who participated for at least three months at a community-based exercise center (participants) were compared with those who did not (nonparticipants). Each completed a baseline physical assessment and periodic reassessments thereafter.
Article Synopsis
- Obesity is linked to a rise in autoimmune diseases, especially in women.
- In female mice that became overweight, researchers found more signs of inflammation in the brain that could lead to multiple sclerosis (MS).
- The study revealed that being overweight causes changes in certain immune cells, and these changes were influenced by hormones and fat in the body.
Background And Objectives: AQP4 antibody-positive NMOSD (AQP4-NMOSD), MOG antibody-associated disease (MOGAD), and seronegative NMOSD (SN-NMOSD) are neuroautoimmune conditions that have overlapping clinical manifestations. Yet, important differences exist in these diseases, particularly in B-cell depletion (BCD) efficacy. Yet, the biology driving these differences remains unclear.
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- The study aimed to find specific autoantibodies in patients with primary Sjögren's syndrome (SS) who test negative for anti-Ro/SS-A antibodies.
- Researchers analyzed plasma samples from SS patients and controls using advanced protein arrays, identifying novel autoantibody specificities in the process.
- The findings suggest that these autoantibodies could help identify a significant portion of Ro seronegative SS cases, potentially improving diagnosis and understanding of the disease.
B cells have emerged as an important immune cell type that can be targeted for therapy in multiple sclerosis (MS). Depleting B cells with anti-CD20 antibodies is effective in treating MS. Yet, atacicept treatment, which blocks B-cell Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL), two cytokines important for B cell development and function, paradoxically increases disease activity in MS patients.
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