Pterygium and associated ocular surface squamous neoplasia.

Objective: To measure the rate of histopathologically identified ocular surface squamous neoplasia (OSSN) in pterygium specimens.

Methods: All pterygium specimens collected from consecutive patients between April 8, 2003, and February 6, 2008, were submitted for histopathologic examination, and the rate of OSSN was calculated.

Results: The rate of OSSN was 9.

Iris melanoma in 12-year-old boy.

A 12-year-old boy presented with an incidental finding of an iris lesion after blunt injury. Ocular examination revealed a large atypical brown vascular nodule in the nasal iris, extending to the pupillary margin. There were smaller scattered nodules scattered within the iris and anterior chamber.

Novel surveillance and cure of a donor-transmitted lymphoma in a renal allograft recipient.

Background: In this report we describe a malignant lymphoma of donor origin inadvertently transplanted into two renal allograft recipients, despite standard comprehensive donor screening. The successful clearance of the tumor from both patients and a novel method of surveillance are detailed.

Methods: Initial management consisted of withdrawal of immunosuppression to promote rejection of the allograft and the transplanted tumor in both patients, followed by graft removal.

Advanced donor-origin melanoma in a renal transplant recipient: immunotherapy, cure, and retransplantation.

Background: A kidney transplant recipient inadvertently contracted donor-origin melanoma, which was found to be very advanced at presentation. Withdrawal of immunosuppression failed to induce rejection, and interferon-alpha was required. When florid allograft rejection was in progress, the allograft was removed, before it was recognized that the transplanted melanoma was not being simultaneously rejected.

Malignant sacrococcygeal germ cell tumour in an adult.

In adults, malignant sacrococcygeal germ cell tumour is a rare cause for a presacral tumour, with only 17 cases having been reported in the literature since 1907. We report the case of a 34 year old male who presented with a 6 month history of symptoms relating to a malignant presacral tumour which required en bloc excision including the lower sacrum and rectum. He died with lung and mediastinal metastasis 7 months following surgical excision and adjuvant chemotherapy using Cisplatin, Bleomycin and Etoposide.