Publications by authors named "R A Ajjan"
Background: Diabetes ranks among the most common chronic conditions in childhood and adolescence. It is unique among chronic conditions, in that clinical outcomes are intimately tied to how the child or adolescent living with diabetes and their parents or carers react to and implement good clinical practice guidance. It is widely recognized that the individual's perspective about the impact of trying to manage the disease together with the burden of self-management should be addressed to achieve optimal health outcomes.
View Article and Find Full Text PDFThe clinical importance of measuring glycaemic variability: Utilising new metrics to optimise glycaemic control.
Diabetes Obes Metab
December 2024
Article Synopsis
- * This review focuses on short-term GV and its potential impact on both microvascular and macrovascular complications, acknowledging that its role in vascular issues is not entirely clear due to varying findings in different populations.
- * Future research is needed to clarify the independent effects of GV versus other factors like hypoglycaemia, with the goal of establishing proper GV targets for optimizing diabetes management and reducing complications.
Hypofibrinolysis is a documented abnormality in conditions with high risk of vascular occlusion. A key inhibitor of fibrinolysis is α2-antiplasmin (α2AP), and we hypothesize that the Affimer technology, comprising small conformational proteins with 2 9-amino-acid variable regions, can be used to modulate α2AP activity and facilitate fibrinolysis. Using a phage display system, a library of Affimers was screened against α2AP.
View Article and Find Full Text PDFArticle Synopsis
- Globally, while people are living longer, many experience a decline in health due to age-related diseases, highlighting the need for better classification systems to address these issues.
- A consensus meeting with 150 experts established criteria for identifying ageing-related pathologies, requiring a 70% agreement for approval among participants.
- The agreed criteria focus on conditions that progress with age, contribute to functional decline, and are backed by human studies, setting a foundation for future classification and staging efforts.