Obsessive-compulsive disorder (OCD) is characterized by unwanted, intrusive and disturbing thoughts or images that cause anxiety and repetitive behaviours or mental acts to relieve these thoughts or images. Considering controversial aetiology of OCD and growing evidence for the role of inflammation in OCD, the aim of this study was to examine the association between OCD and subclinical inflammatory markers, namely neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in adult patients and to investigate the association between antidepressant medications and NLR, PLR. Electronic medical records(EMR) of 24,635 patients aged 18-64 were reviewed and after exclusion of comorbid psychiatric and medical diagnosis 135 EMR of OCD patients were included into final analyses and compared with the healthy control group (n=133).
View Article and Find Full Text PDFObjective: Valproic acid (VPA)-induced hyperammonemia (VIH), is an increase in blood ammonia levels without any alteration of hepatic enzymes, which can occur during VPA treatment. We aimed to determine the prevalence rate and the risk factors for VIH and its association with cognitive functions.
Method: A prospective, cross-sectional study was conducted.
Objective: The aim of this study was to investigate psychosocial functioning of euthymic Bipolar Disorder Type-II (BD-II) patients and the association between psychosocial functioning with cognitive functions and subclinical symptoms. The hypothesis was BD-II patients would have low level of psychosocial functioning comparing to healthy subjects and psychosocial functioning would be associated independently with cognitive dysfunction and subclinical symptoms.
Method: Thirthy-three subjects who met criteria for BD-II according to Structured Clinical Interview for DSM-IV and thirty-five healthy subjects were included.
Aim: Review of clinical and cognitive predictors of psychosocial functioning during the euthymic period in patients with bipolar disorder type II (BD II) was aimed in this paper. Psychosocial functioning status, clinical and cognitive predictors of psychosocial functioning and assessment of psychosocial functioning during the euthymic period in patients with BD-II were discussed.
Method: Studies investigated psychosocial functioning and its clinical and cognitive predictors were reviewed.