Publications by authors named "Quyuan Tao"
Alzheimer's disease (AD) is a neurodegenerative disorder with a higher risk incidence in females than in males, and there are also differences in AD pathophysiology between sexes. The role of sex in the pathogenesis of AD may be crucial, yet the cellular and molecular basis remains unclear. Here, we performed a comprehensive analysis using four public transcriptome datasets of AD patients and age-matched control individuals in prefrontal cortex, including bulk transcriptome (295 females and 402 males) and single-nucleus RNA sequencing (snRNA-seq) data (224 females and 219 males).
View Article and Find Full Text PDFLimited gene capture efficiency and spot size of spatial transcriptome (ST) data pose significant challenges in cell-type characterization. The heterogeneity and complexity of cell composition in the mammalian brain make it more challenging to accurately annotate ST data from brain. Many algorithms attempt to characterize subtypes of neuron by integrating ST data with single-nucleus RNA sequencing (snRNA-seq) or single-cell RNA sequencing.
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- Merkel cell carcinoma (MCC) is a type of skin cancer that involves immune evasion, prompting studies to understand how this occurs in patients.* -
- Using single-cell RNA sequencing, researchers tracked changes in various immune cell types over time in patients with MCC to uncover mechanisms behind immune resistance and disease progression.* -
- The study found that T cell exhaustion and altered monocyte populations contribute to immune evasion and drug resistance in MCC, highlighting the need to address immune system dysfunction in treatment.*
Article Synopsis
- The study investigates the effects of Sijunzi decoction (SJZD) as an adjuvant treatment for colorectal cancer (CRC) by exploring its therapeutic targets and pathways through network pharmacology and the ESTIMATE algorithm.
- The ESTIMATE algorithm was used to assess immune and stromal cell infiltration in CRC, revealing a significant difference in median survival based on stromal scores, while no significant difference was found between immune groups.
- Key findings identified four core genes (HSPB1, SPP1, IGFBP3, TGFB1) that impact CRC progression by influencing processes like hypoxia response and epithelial-mesenchymal transition.
Article Synopsis
- - The study investigates the Huashi Baidu formula (HSBDF), a treatment for severe COVID-19, aiming to identify its active compounds and understand how they combat the SARS-CoV-2 virus using network pharmacology and molecular docking techniques.
- - Researchers analyzed the components of HSBDF, constructed herb-compound-target networks, and assessed the core targets involved, revealing key proteins and numerous signaling pathways connected to the treatment's effectiveness.
- - The findings suggest that baicalein and quercetin are the most effective compounds in HSBDF, interacting strongly with ACE2, potentially regulating multiple pathways to provide therapeutic benefits for COVID-19.