Analysis of Werner's expression within the brain and primary neuronal culture.

Werner's syndrome is a genetic progeria disorder caused by mutation of the Werner gene (WRN). The presence of mutations in the WRN gene is believed to result in a deleterious loss of normal WRN function, which has been best characterized for its role as a DNA helicase and exonuclease. The WRN gene is known to be expressed within the central nervous system, with Werner's syndrome associated with several neuropathological abnormalities including brain atrophy, gliosis and extensive cytoskeletal abnormalities.