Publications by authors named "Quxiang Li"
In this research, a variety of novel amphetamine derivatives were synthesized and assessed for their potential as multifaceted antidepressant agents. Among these compounds, compound demonstrated potent inhibitory effects on both serotonin and noradrenaline transporters (SERT/NET) and high affinity for histamine H receptor (HR), and displayed low affinity for off-target receptors (H1, α1) and hERG channels, which can reduce the prolongation of the QT interval. Molecular docking studies offered a rational binding model of compound when it forms a complex with SERT, NET, and the histamine H receptor.
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- This study focuses on a new series of arylpropylamine compounds designed as potential multi-target antidepressants, with a highlight on compound (R)-13j.
- Compound (R)-13j showed strong inhibition of serotonin and noradrenaline transporters while having low affinity for certain receptors, potentially minimizing side effects.
- In animal tests, (R)-13j significantly reduced signs of depression compared to duloxetine, demonstrating a favorable safety and effectiveness profile, suggesting it could be a promising new treatment for depression.