Publications by authors named "Qurratul Ain Leghari"

Article Synopsis
  • Oxidative stress arises when there's an imbalance between prooxidants and antioxidants, and celecoxib, a COX-2 inhibitor, can cause oxidative harm to the liver despite its effectiveness in reducing pain and inflammation.
  • The study tested the hypothesis that lycopene, a natural antioxidant found in certain fruits and vegetables, could protect rat liver cells from damage caused by celecoxib, through a controlled experiment with three groups of rats receiving different treatments.
  • Results indicated that lycopene effectively reduced liver damage and prevented fat accumulation and glycogen depletion in rats treated with celecoxib, suggesting it may offer protective benefits against oxidative injury and related liver diseases.
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Background: The mental health issues due to COVID-19, such as intolerance of uncertainty (IOU), anxiety, stress, and depression, have attracted extensive attention from researchers. The challenges for Pakistani university students could be worse than developed countries due to the lack of online courses/programs and online mental health support provided by academic institutions. Therefore, the current study aims to assess the intolerance of uncertainty, depression, anxiety, and stress of Pakistani university students after the second wave of COVID-19 and the relationship among these constructs.

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Objective: After the commencement of the Internet and the popularity of various electronic devices, cyberloafing has become prevalent in the workplace regardless of professional type, demographic characteristics, and country. Individuals use the Internet for work-irrelevant purposes during work hours, which is believed to have a controversial role in work productivity. However, rare studies have paid attention to the prevalence of cyberloafing behavior among Pakistan pharmacists.

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Benzimidazole and its derivatives found variety of biological activities, for the searching of its potent anti-inflammatory analogues, we synthesized four novel 4-(2-keto-1-benzimidazollinyl) piperidine derivatives (Q1 to Q4) by refluxing piperidine with substituted imidazole and subjected to in-vitro anti-inflammatory (ROS, NO) and antibacterial activities, structures were elucidated using spectroscopic techniques. Results revealed that compound Q1 showed most effective anti-inflammatory activity with IC 7.6±1.

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In search of potent molecules having antioxidant activity the present work was designed to synthesize 2, 6-diphenylpiperidine-4-one compounds (1a and 1b) and their imine derivatives (2a, 2b, 3a, and 3b). Compounds 1a and 1b were synthesized by Mannich condensation reaction. The method was found to be simple, convenient with high yield and products were easily separated.

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