Antifibrotic potential of Reserpine (alkaloid) targeting Keap1/Nrf2; oxidative stress pathway in CCl-induced liver fibrosis.

The death rate due to liver cancer approaches 2 million annually, the majority is attributed to fibrosis. Currently, there is no efficient, safe, non-toxic, and anti-fibrotic drug available, suggesting room for better drug discovery. The current study aims to evaluate the anti-fibrotic role of reserpine, an alkaloid plant compound against CCl-induced liver fibrosis.

Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis.

B cell immunity carries the inherent risk of deviating into autoimmunity and malignancy, which are both strongly associated with genetic variants or alterations that increase immune signaling. Here, we investigated the interplay of autoimmunity and lymphoma risk factors centered around the archetypal negative immune regulator TNFAIP3/A20 in mice. Counterintuitively, B cells with moderately elevated sensitivity to stimulation caused fatal autoimmune pathology, while those with high sensitivity did not.

Exploring factors associated with domestic violence among pregnant women in Pakistan and its implications for maternal and perinatal health.

Domestic violence during pregnancy is a critical health issue due to its significant implications for both maternal and fetal well-being. Women in South Asian countries are particularly at a higher risk of experiencing domestic violence. The objective of this study was to identify factors associated with domestic violence among pregnant women attending tertiary care antenatal services in Pakistan.

A novel ensemble approach with deep transfer learning for accurate identification of foodborne bacteria from hyperspectral microscopy.

The detection of foodborne bacteria is critical in ensuring both consumer safety and food safety. If these pathogens are not properly identified, it can lead to dangerous cross-contamination. One of the most common methods for classifying bacteria is through the examination of Hyperspectral microscope imaging (HMI).

Exploring antiviral activity of Betanin and Glycine Betaine against dengue virus type-2 in transfected Hela cells.

Dengue virus (DENV) infection is a worldwide public health concern infecting approximately 400 million individuals and about 40,000 mortalities yearly. Despite this, no licensed or readily available antiviral medication is currently available specifically for DENV infection, and therapy is typically symptomatic. Therefore, the objective of the study was to investigate the antiviral activity of Beta vulgaris L.

Jak2 V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk.

JAK2 V617F (JAK2VF) clonal hematopoiesis (CH) has been associated with atherothrombotic cardiovascular disease (CVD). We assessed the impact of Jak2VF CH on arterial thrombosis and explored the underlying mechanisms. A meta-analysis of 3 large cohort studies confirmed the association of JAK2VF with CVD and with platelet counts and adjusted mean platelet volume (MPV).

Domestic Cylinder Blasts: A Neglected Torpedo.

High-pressure cylinders are used to store liquefied petroleum gas (LPG). An instant and swift explosion of these cylinders can result in serious burn injuries. This current research was conducted to study the epidemiological characteristics of LPG-related burns to highlight a major public health issue.

Plasma Levels of Interleukin-6 and -18 Significantly Increase in Patients with Acute Coronary Syndrome.

Objectives: Inflammatory pathways play a significant role in atherosclerosis that leads to acute coronary syndrome (ACS). The initial stages of atherosclerosis are often asymptomatic; when atherosclerotic plaques become unstable it leads to ACS. Therefore, early detection, diagnosis, and treatment of atherosclerosis must be sought.

Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation.

Thrombosis is a frequent cause of cardiovascular mortality and hospitalization. Current antithrombotic strategies, however, target both thrombosis and physiological hemostasis and thereby increase bleeding risk. In recent years the pathophysiological understanding of thrombus formation has significantly advanced and inflammation has become a crucial element.

Solitary wave behavior of (2+1)-dimensional Chaffee-Infante equation.

The behavior of gas diffusion in a homogeneous medium is described by the (2+1)-dimensional Chaffee-Infante equation. In this work, the solitary wave behavior of the (2+1)-dimensional Chaffee-Infante equation is studied with the help of extended sinh-Gordon equation expansion technique. Bright, dark, periodic, kink, anti-kink and singular traveling wave patterns are observed for suitable choice of parameters.

Loneliness and mental health related impacts of COVID-19: a narrative review.

Loneliness is the one of the common phase experienced during COVID-19 pandemic. It has impacted mental health of all ages specifically children and adolescents. The aim of this review was to assess level of loneliness and mental health related impacts of COVID-19 among both; children and adolescents.

Effectiveness of splitter plate to control fluid forces on a circular obstacle in a transient flow: FEM computations.

The reliability of the usage of a splitter plate (passive control device) downstream of the obstacle, in suppressing the fluid forces on a circular obstacle of diameter [Formula: see text] is studied in this paper. The first parameter of the current study is the attachment of a splitter plate of various lengths [Formula: see text] with the obstacle, whereas the gap separation [Formula: see text] between the splitter plate and the obstacle, is used as a second parameter. The control elements of the first and second parameters are varied from [Formula: see text] to [Formula: see text].

Automatically Diagnosing Skin Cancers From Multimodality Images Using Two-Stage Genetic Programming.

Developing a computer-aided diagnostic system for detecting various skin malignancies from images has attracted many researchers. Unlike many machine-learning approaches, such as artificial neural networks, genetic programming (GP) automatically evolves models with flexible representation. GP successfully provides effective solutions using its intrinsic ability to select prominent features (i.

Deep Residual Network for Diagnosis of Retinal Diseases Using Optical Coherence Tomography Images.

Diabetic retinopathy occurs due to damage to the blood vessels in the retina, and it is a major health problem in recent years that progresses slowly without recognizable symptoms. Optical coherence tomography (OCT) is a popular and widely used noninvasive imaging modality for the diagnosis of diabetic retinopathy. Accurate and early diagnosis of this disease using OCT images is crucial for the prevention of blindness.

Probing the chemical constituents of and its analyses as a potent drug.

The phytochemical screening of the crude methanolic stem extracts of plant showed the presence of different classes of organic compounds like alkaloids, tannins, flavonoids, saponins, phlobatanins, steroids, anthraquinone and cardiac glycoside. The starching frequencies of these functional groups were determined from FT-IR spectroscopic data. The crude and their fractions were examined for antibacterial potential against and .

Computational Analysis of Fluid Forces on an Obstacle in a Channel Driven Cavity: Viscoplastic Material Based Characteristics.

In the current work, an investigation has been carried out for the Bingham fluid flow in a channel-driven cavity with a square obstacle installed near the inlet. A square cavity is placed in a channel to accomplish the desired results. The flow has been induced using a fully developed parabolic velocity at the inlet and Neumann condition at the outlet, with zero no-slip conditions given to the other boundaries.

Multi-activity tetracoordinated pallado-oxadiazole thiones as anti-inflammatory, anti-Alzheimer, and anti-microbial agents: Structure, stability and bioactivity comparison with pallado-hydrazides.

Herein, we report a comparative study based on structure, thermal and solution stability, and biopotency against lipoxygenase (LOX), butyrylcholinesterase (BChE) and microbes for Pd(II) compounds of N,O,S bearing 5-(CHXR)-1,3,4-oxadiazole-2-thiones (L') of type [PdL'Cl] (P'n) and N,O bearing respective hydrazides (L) of type trans-[PdLCl] (Pn) {X = C, R = 4-I, 2-Br, 4-NO, 3-NO, 2-Cl, 3-Cl (n = 1-6, serially); X = N (n = 7)}. Spectral techniques (IR, EI-MS, NMR) and physicochemical evaluations successfully characterized the new compounds. The L' behaved as bidentate S-N donors bonded through exocyclic sulfur and N-3' nitrogen, while L acted as amino N donors.

Confounders in Identification and Analysis of Inflammatory Biomarkers in Cardiovascular Diseases.

Proinflammatory biomarkers have been increasingly used in epidemiologic and intervention studies over the past decades to evaluate and identify an association of systemic inflammation with cardiovascular diseases. Although there is a strong correlation between the elevated level of inflammatory biomarkers and the pathology of various cardiovascular diseases, the mechanisms of the underlying cause are unclear. Identification of pro-inflammatory biomarkers such as cytokines, chemokines, acute phase proteins, and other soluble immune factors can help in the early diagnosis of disease.

Common postoperative complications after general anesthesia in oral and maxillofacial surgery.

Aim And Objectives: Anesthesia is Greek word meaning loss of sensation, and involves painful invasive procedure to be performed with little distress and no pain to the patient. Postoperative anesthetic complications are very common and duration of surgery is frequently cited as major risk factor for postoperative complications. The recognition and treatment of these complications are important when providing good quality care.

Concentration and Localization of Fe and Zn in Wheat Grain as Affected by Its Application to Soil and Foliage.

Nutritional status of people can be improved by enhancing zinc (Zn) and iron (Fe) content in cereals used as staple mainly in poor resource countries. Zinc and Fe were applied through soil and foliage in a study to biofortify wheat grains. Foliar application of both micronutrients increased the growth and grain vigor as compared to soil application and control.

COVID-19 highlights the model dilemma in biomedical research.

Scientists worldwide struggle to identify suitable animal models to study SARS-CoV-2 infections. Interspecies-related differences, such as host specificity, divergent immune responses, or the unavailability of species-specific reagents hamper the research. Human-based models, such as micro-engineered multi-organs-on-chip, may hold the solution.

Epidemiology of molecular probes in Xpert MTB/RIF assay in Khyber Pakhtunkhwa, Pakistan.

Regardless of a plethora of advanced diagnostics, TB and drug resistance remains a principal killer. We proposed gold nanoparticles (AuNPs) attached with probes to enhance the efficiency of GeneXpert MTB/RIF assay instead of conventional dye probes for molecular detection. A total of 15,000 samples were collected from TB suspects and subjected to Xpert MTB/RIF assay, where 6800 (45.

Gene Delivery to the Skin - How Far Have We Come?

Gene therapies are powerful tools to prevent, treat, and cure human diseases. The application of gene therapies for skin diseases received little attention so far, despite the easy accessibility of skin and the urgent medical need. A major obstacle is the unique barrier properties of human skin, which significantly limits the absorption of biomacromolecules, and thus hampers the efficient delivery of nucleic acid payloads.