Publications by authors named "Quratulain Qureshi"
Oligomannose-type glycans on HIV-1 gp120 form a patch that is targeted by several broadly neutralizing antibodies (bnAbs) and that therefore is of interest to vaccine design. However, attempts to elicit similar oligomannose-specific bnAbs by immunizing with oligomannosidic glycoconjugates have only been modestly successful so far. A common assumption is that eliciting oligomannose-specific bnAbs is hindered by B cell tolerance, resulting from the presented oligomannosides being sensed as self molecules.
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- - Mantle cell lymphoma (MCL) is a rare type of non-Hodgkin lymphoma that is challenging to treat and has an unclear genetic basis, prompting a large-scale genomic analysis of various MCL samples to identify genetic factors influencing its progression and treatment outcomes.
- - The study confirmed the link between mutations in TP53 and NOTCH1 genes and prognosis in MCL; additionally, researchers found new recurrent noncoding mutations near the HNRNPH1 gene that affect its splicing and contribute to poorer patient outcomes.
- - The results suggest that these mutations disrupt the normal regulation of HNRNPH1 protein expression, indicating that improper messenger RNA processing could play a significant role in the development and severity of MCL.
Aims: The establishment of a vascular surgeon-led emergency diabetic foot service in 2006 has evolved to provide lower limb wound care for patients with and without diabetes. We aimed to determine whether the service was associated with sustained, improved limb salvage rates for the whole population, analyse key aspects of service provision and compare outcomes against published studies.
Methods: The vascular unit serves a largely rural population of approximately 240,000.