The Landscape of Genetic Alterations Stratified Prognosis in Oriental Pancreatic Cancer Patients.

Background: Pancreatic cancer is a life-threatening malignant disease with significant diversity among geographic regions and races leading to distinct carcinogenesis and prognosis. Previous studies mainly focused on Western patients, while the genomic landscape of Oriental patients, especially Chinese, remained less investigated.

Methods: A total of 408 pancreatic cancer patients were enrolled.

Genetic Profiling of Breast Cancer with and Without Preexisting Metabolic Disease.

Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women. Various mechanisms are involved in the initiation and progression of breast cancer. Metabolic dysregulation has been associated with increasing breast cancer incidence and mortality.

Gene expression profiles of glucose toxicity-exposed islet microvascular endothelial cells.

Objective: Islet microcirculation is mainly composed by IMECs. The aim of the study was to investigate the differences in gene expression profiles of IMECs upon glucose toxicity exposure and insulin treatment.

Methods: IMECs were treated with 5.