Spatiotemporal transcriptomic atlas reveals the dynamic characteristics and key regulators of planarian regeneration.

Whole-body regeneration of planarians is a natural wonder but how it occurs remains elusive. It requires coordinated responses from each cell in the remaining tissue with spatial awareness to regenerate new cells and missing body parts. While previous studies identified new genes essential to regeneration, a more efficient screening approach that can identify regeneration-associated genes in the spatial context is needed.

Cross-species cell-type assignment from single-cell RNA-seq data by a heterogeneous graph neural network.

Cross-species comparative analyses of single-cell RNA sequencing (scRNA-seq) data allow us to explore, at single-cell resolution, the origins of the cellular diversity and evolutionary mechanisms that shape cellular form and function. Cell-type assignment is a crucial step to achieve that. However, the poorly annotated genome and limited known biomarkers hinder us from assigning cell identities for nonmodel species.

Approximate distance correlation for selecting highly interrelated genes across datasets.

With the rapid accumulation of biological omics datasets, decoding the underlying relationships of cross-dataset genes becomes an important issue. Previous studies have attempted to identify differentially expressed genes across datasets. However, it is hard for them to detect interrelated ones.