Publications by authors named "Qunhui Wei"
Article Synopsis
- The MRN complex is essential for sensing DNA double-strand breaks (DSBs) and triggering repair signaling, but how it gets recruited needs more study.* -
- Researchers discovered that the TRIM24 protein, linked to cancer, plays a key role in recruiting the MRN complex to DSB sites and activating the repair process.* -
- TRIM24's phosphorylation by ATM is crucial for its function, and reducing TRIM24 levels increases the susceptibility of cancer cells to treatment and slows tumor growth, indicating it could be a target for future cancer therapies.*
Colorectal cancer (CRC) is one of the most common malignant tumors. 5-fluorouracil (5-FU) has been used for the standard first-line treatment for CRC patients for several decades. Although 5-FU based chemotherapy has increased overall survival (OS) of CRC patients, the resistance of CRC to 5-FU based chemotherapy is the principal cause for treatment failure.
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