Publications by authors named "Qunhao Huang"
Article Synopsis
- N6-methyladenosine (m6A) is important for various biological processes, but its role during oocyte maturation in domestic animals, particularly in granulosa cells, is not well understood.
- Observations show an increase in m6A methyltransferase-like 3 (METTL3) in granulosa cells during maturation in Haimen goats, with knockdown of METTL3 causing cell cycle disruptions, increased apoptosis, and decreased hormone secretion.
- METTL3 regulates the cell cycle by promoting Aurora kinase B (AURKB) mRNA degradation and is involved in AURKB transcription through the Cyclin D1-Retinoblastoma-E2F1 pathway, emphasizing its crucial role in granulosa cells during o
Neuromedin S (NMS) is a neuroregulatory substance and has many important roles in regulating physiological functions in animal cells, while their specific functions and mechanisms in Leydig cells (LCs) of the testis remain unclear. The current study aims to investigate the role and potential mechanisms of NMS and its receptors in regulating steroidogenesis and proliferation in goat LCs. We found that NMS and its receptors were mainly expressed in LCs of goat testes at different ages (1-day-old, 3-month-old, and 9-month-old), and the highest expressions detected at age three months.
View Article and Find Full Text PDFRecent evidence suggested that N6-methyladenosine (mA) methylation can determine mA-modified mRNA fate and play an important role in skeletal muscle development. It was well known that transforming growth factor beta 1 (TGFβ1) is involved in a variety of cellular processes, such as proliferation, differentiation, and apoptosis. However, little is known about the mA-mediated TGFβ1 regulation in myogenesis.
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