Publications by authors named "Qunfang Cai"
Toxicarioside G (TCG), a natural product isolated from , has been found to exhibit potent anticancer effects. The present study aimed to investigate the effect of TCG on the SW480 colorectal cancer cell line and the role of autophagy and Yes1 associated transcriptional regulator (YAP) in the TCG‑mediated inhibition of cell proliferation and viability. Cell proliferation was detected using MTT, BrdU, colony formation and LDH release assays, while apoptosis was analyzed using flow cytometry and western blot analyses.
View Article and Find Full Text PDFBackground: Type 2 diabetes mellitus (T2DM) occurs around the world with high prevalence and causes serious physical harm and economic burden to the afflicted. Haikou City is China's southernmost tropical island city, which has not been previously studied for its T2DM prevalence. The objective of the study in employing a cross-sectional survey is to discuss the epidemiologic status of T2DM in Haikou City and to analyze the possible determinants.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to identify and analyze a novel tetraspanin (TSP) homologue in Spirometra erinaceieuropaei through bioinformatics to understand its structure and function.
- - The target sequence obtained was 1132 bp long, with a significant open reading frame encoding a protein (SeTSP16) of 226 amino acids, showing conservation with TSP from similar parasites but with distinct epitopes.
- - Findings suggest that the identified SeTSP16 could serve as a potential diagnostic antigen and therapeutic target for antiparasitic treatments.
Objective: To obtain fbpB-esxA fusing gene of Mycobacterium tuberculosis (MTB), express the encoded fusing protein in Escherichia coli (E. coli), identify protein acquired, and predict the structure and function of the protein utilizing methods of bioinformatics.
Methods: fbpB and esxA gene were amplified from genome of MTB H37Rv by PCR.