MRI assessment of amplitude of low-frequency fluctuation in rat brains with acute cerebral ischemic stroke.

To investigate fluctuations in the amplitude of low-frequency blood oxygenation level-dependent (BOLD) fMRI during acute brain ischemia, and to evaluate the use of amplitude of low-frequency fluctuations (ALFFs) in resting state fMRI for assessing super-acute focal cerebral ischemic stroke. A super-acute stroke model with middle cerebral artery occlusion (MCAO) in the rat was employed. Spontaneous fluctuations were recorded using a series of gradient echo-planar imaging (EPI) images before and 30 min, 60 min, 2 h, 6 h, 12 h, and 24 h after MCAO.

[Functional connectivity analysis of super acute cerebral ischemia in rats: a resting-state functional MRI empirical study].

Objective: To investigate the change of low-frequency blood-oxygenation-level-dependent fluctuation (LFBF) after cerebral ischemia by functional connectivity analysis in the resting state.

Methods: Super acute stroke rat-models with middle cerebral artery occlusion (MCAO) were employed in this study. Spontaneous fluctuations were recorded using a series of gradient-recalled echo-planar imaging (EPI) images before creation of the MCAO, and the same scan protocols were duplicated at the time of 60 min, 2 h after creation of the MCAO.

Efficient nano iron particle-labeling and noninvasive MR imaging of mouse bone marrow-derived endothelial progenitor cells.

In this study, we sought to label mouse bone marrow-derived endothelial progenitor cells (EPCs) with Resovist(®) in vitro and to image them using 7.0 Tesla (T) magnetic resonance imaging (MRI). Mouse bone marrow-derived EPCs were cultured in endothelial basal medium with endothelial growth supplement.

[A study of ischemic penumbra by perfusion and diffusion-weighted imaging at high-field MRI (7.0 T)].

Objective: To approach the value of perfusion-weighed and diffusion-weighted imaging at high field intensity (7.0 T) MR in research of the ischemic penumbra in acute cerebral infarction of rats.

Methods: Acute cerebral infarction of rat was induced by occluding middle cerebral artery (MCAO) with suture.