Publications by authors named "Qun-ji Wang"
Objective: To investigate the role and significance of FHIT genes depletion, p53 overexpression and HPV16/18 infection in cervical intraepithelial neoplasia (CIN) and cervical carcinoma (CC).
Methods: Tumor samples taken from 52 cases of CIN and 69 cases of CC were processed by immunohistochemistry (SP) to determine the expression of FHIT genes and p53 protein, by in situ hybridization to detect HPV16/18 infection, and were compared with those in 18 cases of normal cervical tissues as control.
Results: (1) The FHIT expression was positive in normal cervical tissue with no depletion occurred, and was 30.
Background & Objective: It is demonstrated that endothelin-1 (ET-1) is synthesized by and released from certain malignant tumor cells, and it plays an important role in growth and development of tumor. This study was designed to investigate the expression of ET-1 in astrocytomas and the relationship between the ET-1 quantity and the grades of astrocytomas.
Method: ET-1 expression was determined in 70 astrocytoma specimens using Streptavidin-Peroxidase method and image analysis technology.
[Effect and mechanism of chimonin on pulmonary hypertention of chronic hypoxia and hypercapnic rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
February 2002
Article Synopsis
- The study investigates the impact of chimonin on chronic hypoxia and hypercapnic pulmonary hypertension in rats, focusing on its mechanisms.
- The research involves dividing rats into three groups—normal control, hypoxic hypercapnic, and hypoxic hypercapnic with chimonin—while assessing pulmonary arterioles through various microscopic techniques.
- Findings indicate that chimonin significantly reduces elevated mean pulmonary arterial pressure and improves conditions related to vascular structure and smooth muscle density, primarily by increasing the expression of HO-1 mRNA.