Publications by authors named "Qun-Qun Zhang"
Article Synopsis
- Plasmodium falciparum malaria poses a significant health risk globally, leading to research on the PfCSP protein as a potential vaccine target despite its genetic variability affecting vaccine effectiveness.
- The study analyzed blood samples from 287 Chinese migrant workers returning from Africa, identifying key genetic variations in the PfCSP gene, including notable mutations and a high level of nucleotide diversity.
- Findings indicated that while certain regions of the PfCSP gene were conserved, others showed signs of positive selection and moderate genetic differentiation between various African populations, providing insights for vaccine development.
Ethnopharmacological Relevance: Monascus-fermented rice product (MFRP) has been regarded as a dietary supplement and traditional medicine with circulation-promoting effects in China and other countries for centuries.
Aim Of The Study: This study was carried out to profile the chemical components in MFRP, and provide available information for elucidating the potential lipid-lowering compounds other than monacolins.
Materials And Methods: High-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-QTOF MS) and gas chromatography coupled with mass spectrometry (GC-MS) methods were applied to comprehensive analysis of chemical components in MFRP.
Objective: To identify and compare the constituents in different processed products of Ligubtrum lucidum fruit by HPLC fingerprint, in order to study the changes of chemical constituents before and after processing.
Methods: HPLC analysis was carried outwith the mobile phase of acetonitrile and 0.1% formic acid in a gradient elution mode.
To characterize and identify multiple constituents in Danhong injection (DHI), a fast ultra-high performance liquid chromatography coupled to electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UHPLC-ESI-QTOF/MS) method was established and validated in the present study. A total of 63 compounds, including 33 phenolic acids, 2 C-glycosyl quinochalcones, 6 flavonoid O-glycosides, 4 iridoid glycosides, 6 organic acids, 5 amino acids, and 3 nucleosides, were identified or tentatively characterized. In conclusion, the UHPLC-ESI-QTOF/MS method is useful and efficient for in-depth structural elucidation of chemical compounds in complex matrices of herbal medicines such as DHI.
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