Publications by authors named "Qun-Hua Bai"
The metabolic mechanisms for imidazolidine oxidation of imidacloprid (IMI) by cytochrome P450 3A4 (CYP3A4) have been investigated using quantum mechanical/molecular mechanical (QM/MM) calculations. The binding mode of CYP3A4 with IMI is examined by molecular docking in collaboration with molecular dynamics (MD) simulations. The results show that there are six amino acid residues, involving Arg192, Phe195, Ile349, Ala285, Phe284 and Phe88, closely distributed around the IMI.
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- Chitosan oligosaccharides (COS) exhibit various biological activities, including antioxidant and anti-inflammatory effects.
- In a study on LPS-induced N9 microglial cells, COS pretreatment significantly reduced nitric oxide (NO) production by inhibiting the expression of inducible nitric oxide synthase (iNOS).
- COS also prevented the activation of key signaling pathways such as p38 MAPK, ERK1/2, and the nuclear factor-κB (NF-κB) pathway, suggesting its potential role in modulating inflammatory responses.
[Puerarin antagonizes activation effect of LPS on N9 microglia cells].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
March 2010
Aim: To investigate the effect of puerarin on lipopolysaccharide (LPS)-activated N9 microglia cells.
Methods: MTT was used to detect the cytotoxic effect of puerarin and LPS on N9 microglia cells. Flow cytometry was used to determine the effect of puerarin on cellular production of nitric oxide (NO) and reactive oxygen species (ROS), apoptosis and cell cycle in LPS-activated N9 microglia cells.