Wave propagation in a light-temperature neural network under adaptive local energy balance.

External electric and mechanical stimuli can induce shape deformation in excitable media because of its intrinsic flexible property. When the signals propagation in the media is described by a neural network, creation of heterogeneity or defect is considered as the effect of shape deformation due to accumulation or release of energy in the media. In this paper, a temperature-light sensitive neuron model is developed from a nonlinear circuit composed of a phototube and a thermistor, and the physical energy is kept in capacitive and inductive terms.

IBI310 (anti-CTLA-4 antibody) monotherapy or in combination with sintilimab in advanced melanoma or urothelial carcinoma.

IBI310 is a recombinant fully human IgG1 antibody against cytotoxic T lymphocyte antigen 4. This study was conducted to evaluate IBI310 monotherapy or combination therapy with sintilimab in the patients with advanced melanoma or urothelial carcinoma (UC). Patients in phase 1a received IBI310 at 0.

Diverse responses of surface biogeophysical parameters to accelerated development and senescence of vegetation on the Mongolian Plateau.

Vegetation dynamics is essential for characterizing surface biogeophysical parameters. Speeds of vegetation development and senescence are well documented, however, the effects of vegetation growth rates on surface parameters during different growth stages remains unclear. By using such methods as trend analyses and correlation analyses, this study examines the variations and interactive relationships of leaf area index (LAI) and surface parameters including Albedo, evapotranspiration (ET), and land surface temperature (LST), derived from Moderate Resolution Imaging Spectroradiometer (MODIS), during the intra-growing season (April-October, GS) on the Mongolian Plateau (MP).

A neuron model with nonlinear membranes.

One-layer membrane separates the gradient field in and out of the cell, while some two-layer membranes filled with excitable media/material are important to regulate the energy flow when ions are propagated and diffused. The intracellular and extracellular media can be effectively separated by the membrane. It is important to clarify and describe the biophysical function and then the capacitive property can be reproduced in equivalent neural circuit.

Genetic testing for fetal loss of heterozygosity using single nucleotide polymorphism array and whole-exome sequencing.

The study explored the clinical significance of fetal loss of heterozygosity (LOH) identified by single-nucleotide polymorphism array (SNP array). We retrospectively reviewed data from pregnant women who underwent invasive diagnostic procedures at prenatal diagnosis centers in southeastern China from December 2016 to December 2021. SNP array was performed by the Affymetrix CytoScan 750 K array platform.

A phase Ib study evaluating the safety and efficacy of IBI310 plus sintilimab in patients with advanced non-small-cell lung cancer who have progressed after anti-PD-1/L1 therapy.

Background: The development of immune checkpoint inhibitors has made a significant breakthrough in the treatment of non-small-cell lung cancer (NSCLC). However, there remains a huge unmet clinical need for patients with acquired resistance after initial treatment response.

Methods: This study evaluated the combination of IBI310 (an anti-cytotoxic T lymphocyte-associated antigen-4 [CTLA-4] antibody) and sintilimab (an anti-programmed death 1 [PD-1]) antibody) in NSCLC patients who have previously been treated with anti-PD-1/ligand (L)1 and acquired resistance.

Genetic analysis of chorionic villus tissues in early missed abortions.

Chromosomal abnormalities are the most common etiology of early spontaneous miscarriage. However, traditional karyotyping of chorionic villus samples (CVSs) is limited by cell culture and its low resolution. The objective of our study was to investigate the efficiency of molecular karyotyping technology for genetic diagnosis of early missed abortion tissues.

Effect of Modified Cellulose Nanocrystals on the Structure of Calcium Silicate Hydrate Studied by Molecular Dynamics Simulation and Experiment.

The interfacial bonding of the four cellulose nanocrystals (CNCs) and calcium silicate hydrate (C-S-H) in vacuum and solution conditions was analyzed by molecular dynamics simulation. The binding energies were calculated, and the sources of interface strength were analyzed by the formation and lifetime of hydrogen bonds. The adsorption between CNC/C-S-H was characterized by the movement of interfacial atoms and CNC's adsorption conformation.

Diverse responses of gross primary production and leaf area index to drought on the Mongolian Plateau.

Drought is a crucial factor regulating vegetation growth on the Mongolian Plateau (MP). Previous studies of drought effects on the MP have mainly concentrated on drought characterization, while the response of vegetation to drought remains unclear. To close this knowledge gap, we examined the response of MP vegetation to drought in terms of gross primary production (GPP) and leaf area index (LAI) from 1982 to 2018.

Prenatal genetic analysis of fetal aberrant right subclavian artery with or without additional ultrasound anomalies in a third level referral center.

To evaluate the correlation between chromosomal abnormalities and fetal aberrant right subclavian artery (ARSA) with or without additional ultrasound anomalies (UAs). A total of 340 fetuses diagnosed with ARSA by ultrasound between December, 2015, and July, 2021, were included. All cases were subdivided into three groups: (A) 121 (35.

Predicting N2 lymph node metastasis in presurgical stage I-II non-small cell lung cancer using multiview radiomics and deep learning method.

Background: Accurate diagnosis of N2 lymph node status of the resectable stage I-II non-small cell lung cancer (NSCLC) before surgery is crucial, while there is lack of corresponding method clinically.

Purpose: To develop and validate a model to quantitively predict the N2 lymph node metastasis in presurgical clinical stage I-II NSCLC using multiview radiomics and deep learning method.

Methods: In this study, 140 NSCLC patients were enrolled and randomly divided into training and test sets.

Efficiency of expanded noninvasive prenatal testing in the detection of fetal subchromosomal microdeletion and microduplication in a cohort of 31,256 single pregnancies.

Noninvasive prenatal testing (NIPT) is widely used to screen for common fetal chromosomal aneuploidies. However, the ability of NIPT-Plus to detect copy number variation (CNV) is debatable. Accordingly, we assessed the efficiency of NIPT-Plus to detect clinically significant fetal CNV.

Corrigendum: Chromosomal abnormalities and pregnancy outcomes for fetuses with gastrointestinal tract obstructions.

[This corrects the article DOI: 10.3389/fped.2022.

Analysis of Carbonation Behavior of Cracked Concrete.

The crack and carbonation of concrete pose a great challenge to its durability. Therefore, this paper studies the effect of cracks on the carbonation depth of cement paste under different factors. The relationship between carbonation and cracks was determined, and the carbonation mechanism of cement paste with cracks was clarified.

Chromosomal Abnormalities and Pregnancy Outcomes for Fetuses With Gastrointestinal Tract Obstructions.

Fetal gastrointestinal tract obstruction (GITO) is the most frequently encountered gastrointestinal defect in the prenatal period. This study aimed to investigate the genetic disorders and pregnancy outcomes of fetal GITO. We reviewed data from 70 pregnancies that were referred for invasive prenatal testing because of fetal GITO.

Assessment of vegetation change on the Mongolian Plateau over three decades using different remote sensing products.

As a major component of temperate steppes in the Eurasian continent, the Mongolian Plateau (MP) plays a pivotal role in the East Asian and global carbon cycles. This paper describes the use of five remote sensing indices derived from satellite data to characterize vegetation cover on MP, namely: gross primary production (GPP), net primary production (NPP), normalized difference vegetation index (NDVI), leaf area index (LAI) and fractional vegetation cover (FVC). It is found that GPP, NPP, and NDVI exhibit increasing trends, whereas LAI and FVC present decreasing trends on the MP since 1982.

How Narcissistic Leaders Impact on Subordinate's Followership During the COVID-19? The Moderating Role of Organizational Identification.

The COVID-19 pandemic gave rise to social and economic problems and pose a threat to most of enterprise. Faced with crisis and challenge, effective leaders and devoted employees are important factors for enterprises to overcome difficulties. We propose a moderated mediation model wherein narcissistic leader predicts subordinate's followership through leader self-interest behavior perceived by subordinates, with organizational identification of leader acting as the contextual condition.

Association between air pollution and outpatient visits for allergic rhinitis: Effect modification by ambient temperature and relative humidity.

Mounting evidence indicated the associations between air pollution and outpatient visits for allergic rhinitis (AR), while few studies assessed the effect modification of these associations by ambient temperature and relative humidity (RH). In this study, dataset of AR outpatients was obtained from Chinese People's Liberation Army Strategic Support Force Characteristic Medical Center in Beijing during 2014 to 2019, and the average concentrations of air pollutants including particulate matter ≤2.5 μm in diameter (PM) and ≤10 μm (PM), nitrogen dioxide (NO), sulfur dioxide (SO), and meteorological factors (temperature and RH) at the same period were collected from one nearby air monitoring station.

Proangiogenic functions of osteopontin-derived synthetic peptide RSKSKKFRR in endothelial cells and postischemic brain.

Objective: The aim of this study was to investigate the potential therapeutic effects of a newly discovered osteopontin-derived synthetic peptide "RSKKFRR" in a rat model of ischemic stroke.

Methods: A total of 24 male SD rats were randomly divided into three groups. The model of ischemic stroke was made up of the middle cerebral artery occlusion (MACO).

[Soil acidification induced by nitrogen addition and its responses to water addition in Inner Mongolia Temperate Steppe, China].

Soil acidification due to exogenous nitrogen (N) deposition has been received sufficient attention in the past several decades. Whether the N-induced soil acidification is modulated by the altering precipitation regimes remains unclear. In this study, based on a five-year (2013-2017) manipulative field experiment with factorial N addition (10 and 40 g N·m·a ) and water addition (a total amount of 80 mm·a was added in terms of five intensities, i.

[Responses of grassland ecosystem productivity to altered precipitation regime: A review.].

Under global change scenario, precipitation pattern has significantly changed, mainly in the aspects of annual precipitation amount, precipitation seasonal distribution and precipitation event characteristics (size of individual precipitation event, periods length between two precipitation events, and number of precipitation events in a year), which combined to affect various processes of terrestrial ecosystems, especially productivity. Grassland ecosystem is one of the most sensitive ecosystems to the changes of precipitation regime. Therefore, it is necessary to clarify the responses of productivity to altered precipitation regime in grasslands.

Ambient air pollution and the hospital outpatient visits for eczema and dermatitis in Beijing: a time-stratified case-crossover analysis.

Background: Eczema and dermatitis are a group of common skin conditions with multiple risk factors. Evidence of the effects of air pollutants on eczema and dermatitis remains limited. This study aimed to investigate the effects of short-term exposure to air pollution on eczema and dermatitis in Beijing.