Publications by authors named "Quinn O'Brien"
Article Synopsis
- Ewing sarcoma (ES) is challenging to treat because it's hard to directly target its main driver, EWS::FLI1.
- Researchers found that inhibiting P300/CBP, which is part of the EWS::FLI1 complex, mimics knocking down EWS::FLI1 and can indicate patient outcomes.
- By reversing EWS::FLI1's effects through P300 inhibition, ES cells enter senescence and can be targeted with senolytics that hit the PI3K pathway, suggesting a promising combination therapy for treating ES.
