Publications by authors named "Quilianio Contreras"
Article Synopsis
- The study examined how olanzapine affects insulin counter-regulatory factors, fibrinogen, and C-reactive protein levels in patients with chronic schizophrenia, along with the impact of metformin on these factors.
- 37 patients were given olanzapine for 14 weeks, with 19 receiving metformin and 18 receiving a placebo in a randomized trial.
- Results showed decreased levels of cortisol, tumor necrosis factor-alpha, and fibrinogen in both groups, with metformin showing a potential beneficial effect despite not preventing weight gain associated with olanzapine.
The periaqueductal gray matter (PAG) is an important center in the modulation of behavioral responses during nociception and stress. In the present experiment, extracellular excitatory amino acid overflow in the PAG was measured every 30 s during noxious stimulation. A combination of in vivo brain microdialysis in freely moving rats and capillary zone electrophoresis with laser induced-fluorescence detection allowed us to detect short lasting changes of excitatory amino acid in dialysates.
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