Publications by authors named "Qui-Hien Nguyen"
The development of catalytic enantioselective transformations, enabling the construction of complex molecular scaffolds from simple precursors, has been a long-standing challenge in organic synthesis. Recent achievements in transition-metal catalyzed enantioselective functionalizations of carbon-hydrogen (C-H) bonds represent a promising pathway toward this goal. Over the last two decades, iridium catalysis has evolved as a valuable tool enabling the stereocontrolled synthesis of chiral molecules via C-H activation.
View Article and Find Full Text PDFAtropisomeric (hetero)biaryls are motifs with increasing significance in ligands, natural products, and biologically active molecules. The straightforward construction of the stereogenic axis by efficient C-H functionalization methods is extremely rare and challenging. An intermolecular and highly enantioselective C-H arylation of relevant heteroarenes providing an efficient access to atropisomeric (hetero)biaryls is reported.
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- Fluorinated carbohydrates are used as tools to study protein-carbohydrate interactions and to create enzyme inhibitors, leading to a need for new fluorinated carbohydrate probes.
- While most existing studies focus on sugars with one fluoride atom, there's growing interest in sugars with multiple fluoride atoms.
- This research introduces new dideoxy-difluorinated d-galactoses with specific fluorination positions, including methods to convert pyranose forms to furanose forms.