Publications by authors named "Quentin E Adams"
Background: Intensity modulated brachytherapy based on partially shielded intracavitary and interstitial applicators is possible with a cost-effective Yb production method. Yb is a traditionally expensive isotope suitable for this purpose, with an average γ-ray energy of 93 keV. Re-activating a single Yb source multiple times in a nuclear reactor between clinical uses was shown to theoretically reduce cost by approximately 75% relative to conventional single-activation sources.
View Article and Find Full Text PDFBackground: Multiple approaches are under development for delivering temporary intensity modulated brachytherapy (IMBT) using partially shielded applicators wherein the delivered dose distributions are sensitive to spatial uncertainties in both the applicator position and shield orientation, rather than only applicator position as with conventional high-dose-rate brachytherapy (HDR-BT). Sensitivity analyses to spatial uncertainties have been reported as components of publications on these emerging technologies, however, a generalized framework for the rigorous determination of the spatial uncertainty tolerances of dose-volume parameters is needed.
Purpose: To derive and present the population percentile allowance (PPA) method, a generalized mathematical and statistical framework to evaluate the tolerance of temporary IMBT approaches to spatial uncertainties in applicator position and shield orientation.
Article Synopsis
- * A theoretical model was developed for activating Yb sources using thermal neutrons, focusing on the enrichment percentage of Yb precursor, active source volume, and neutron flux.
- * Results indicate significant efficiency improvements in Yb source production through reactivation, with reductions in production time and precursor amounts when increasing the source volume from 1 mm to 3 mm, suggesting potential cost savings.
Purpose: To present a novel needle, catheter, and radiation source system for interstitial rotating shield brachytherapy (I-RSBT) of the prostate. I-RSBT is a promising technique for reducing urethra, rectum, and bladder dose relative to conventional interstitial high-dose-rate brachytherapy (HDR-BT).
Methods: A wire-mounted 62 GBq(153)Gd source is proposed with an encapsulated diameter of 0.