Pregnancy and the eye: What do we need to watch out for? A review.

Pregnancy causes changes in all body systems, including the eye. The eye can undergo physiological and pathological changes in pregnancy. Some changes exacerbate pre-existing eye conditions while other conditions manifest for the first-time during pregnancy.

Ophthalmic associations in pregnancy.

Background: A range of ocular pathology exists during pregnancy. Some pre-existing eye conditions, such as diabetic retinopathy, can be exacerbated during pregnancy. Other conditions manifest for the first time during pregnancy as a result of complications such as pre-eclampsia and eclampsia.

Bleb vascularity following post-trabeculectomy subconjunctival bevacizumab: a pilot study.

Background: To determine whether postoperative subconjunctival bevacizumab significantly alters bleb vascularity.

Design: A randomized, prospective interventional study.

Participants: Forty-three eyes from 39 patients were recruited, with 21 eyes randomized to subconjunctival injections of 5-fluorouracil, and 22 eyes to combined 5-fluorouracil/bevacizumab.

Antifibrotic activity of bevacizumab on human Tenon's fibroblasts in vitro.

Purpose: To evaluate the effect of the anti-VEGF-A monoclonal antibody bevacizumab on primary human Tenon's capsule fibroblasts (HTFs) in an in vitro model of wound healing.

Methods: Fibroblasts were cultured in RPMI media, and bevacizumab was administered at a concentration ranging from 0.25 to 12.

Vascular changes after intra-bleb injection of bevacizumab.

Purpose: To illustrate changes in bleb vascularity after subconjunctival bevacizumab injection.

Methods: Longitudinal changes in bleb vascularity were followed over 6 months pre and postbevacizumab injection.

Results: Bleb vascularity associated with increased scarring activity was observed 10 days postcataract surgery in an eye that had undergone trabeculectomy 3 months previously.