Purpose: The new CAP guideline published in August 2022 recommends using immunohistochemistry (IHC) to test for mismatch repair defects in gastroesophageal (GE), small bowel (SB), or endometrial carcinoma (EC) cancers over next-generation sequencing assessment of microsatellite instability (NGS-MSI) for immune checkpoint inhibitor (ICI) therapy eligibility and states there is a preference to use IHC over NGS-MSI in colorectal carcinoma (CRC).
Methods: We assessed the concordance of NGS-MSI and IHC-MMR from a very large cohort across the spectrum of solid tumors.
Results: Of the over 190,000 samples with both NGS-MSI and IHC-MMR about 1,160 were initially flagged as discordant.
The deployment of magnetically responsive and polymeric materials to remove dyes that are hazardous in aquatic environments has profoundly revolutionized environmental sustainability. This study focuses on removing the hazardous cationic Malachite Green (MG) dye from solutions, employing a novel magnetic composite film as an adsorbent, designated as AgCo FeO (ACFCeP). The composite was synthesized solvent casting, incorporating AgCo FeO nanoparticles and CeO into a cellulose acetate/polyvinylpyrrolidone (CA/PVP) polymer matrix.
View Article and Find Full Text PDFObjective: We report the first documented case of concurrent ectopic complete hydatidiform mole (CHM) and high-grade serous carcinoma (HGSC) of the fallopian tube, associated with unique histologic features and mutations in the HGSC.
Case Report: The patient presented with pelvic pain and vaginal bleeding. Laboratory examination revealed a positive urine pregnancy test and high serum beta-human chorionic gonadotropin (β-hCG).
One of the main objectives in improving the quality of life for individuals with disabilities, especially those experiencing mobility issues such as the elderly, is to enhance their day-to-day mobility. Enabling easy mobility contributes to their independence and access to better healthcare, leading to improvements in both physical and mental well-being. Mobility Scooters have become increasingly popular in recent years as a means of facilitating mobility, yet traffic safety issues such as crash severity have not been adequately investigated in the literature.
View Article and Find Full Text PDFThe FIGO scheme is currently applied for tumor grading of endometrioid adenocarcinoma. The current report presents a series of ten cases of endometrioid carcinomas that when applying the FIGO grading does not fully convey the true biological nature of the disease. The squamous component of these tumors is malignant; it constitutes the predominant invasive component, and it often metastasizes to unconventional sites.
View Article and Find Full Text PDFVertically aligned ZnO nanorods (NRs) were grown hydrothermally on the wide bandgap (∼3.86 - 4.04 eV) seed layers (SLs) of grain size ∼162 ± 35 nm, prepared using ball-milled derived ZnO powder.
View Article and Find Full Text PDFThe emerging connected vehicle (CV) technologies facilitate the development of integrated advanced driver assistance systems (ADASs), with which various functions are coordinated in a comprehensive framework. However, challenges arise in enabling drivers to perceive important information with minimal distractions when multiple messages are simultaneously provided by integrated ADASs. To this end, this study introduces three types of human-machine interfaces (HMIs) for an integrated ADAS: 1) three messages using a visual display only, 2) four messages using a visual display only, and 3) three messages using visual plus auditory displays.
View Article and Find Full Text PDFDeleterious germline mutations in multiple genes confer an increased breast cancer (BC) risk. Immunohistochemical (IHC) expression of protein products of mutated high-risk genes has not been investigated in BC. We hypothesized that pathogenic mutations may lead to an abnormal IHC expression pattern in the tumor cells.
View Article and Find Full Text PDFMobility and environmental benefits of Green Light Optimal Speed Advisory (GLOSA) systems have been reported by many previous research studies, however, there is insufficient knowledge on the safety implications of such an application. For safe deployment of GLOSA system, it is most critical to identify and address potential safety issues in the design process. It can be argued that implementation of GLOSA system can improve safety by reducing traffic conflicts associated with the interrupted traffic flow at signalised intersections.
View Article and Find Full Text PDFObjectives: To study the expression of HER2 in high-grade FIGO3 endometrial endometroid carcinoma (EEC) and to correlate our findings with the clinicopathologic characteristics of this tumor.
Methods: HER2 expression by immunohistochemistry (IHC) was performed on 10% formalin-fixed paraffin embedded tissue on cases diagnosed as FIGO3 EEC. HER2 expression was interpreted as negative (0), low (1+ and 2+) or positive (3+) using similar criteria as in the breast.
Mesonephric-like adenocarcinoma (MLA) of the endometrium shows a variety of morphologic appearances, including small glands, tubules with eosinophilic materials in the lumen, prominent papillary patterns, spindled cells, solid formations, and corded and hyalinized patterns. Unique morphology, characteristic immunohistochemical staining patterns, molecular alterations, and awareness of the pathologists make it possible to identify this tumor accurately. This report of two additional morphologic patterns, intestinal goblet cells mimicking intestinal-type mucinous carcinoma and squamous differentiation with spindle and epithelioid cells mimicking carcinosarcoma of the endometrium will expand the literature on MLA.
View Article and Find Full Text PDFSalinity variations are the main reason for rice yield fluctuations in salt-prone regions throughout the dry season (Boro season). Plant breeders must produce new rice varieties that are more productive, salt tolerant, and stable across a variety of settings to ensure Bangladesh's food sustainability. To assess the yield and stability, we used fifteen rice genotypes containing two tolerant checks BRRI dhan67, Binadhan-10 and the popular Boro rice variety BRRI dhan28 in different salinity "hotspot" in three successive years followed by additive main effects and multiplicative interaction (AMMI) model utilizing a randomized complete block (RCB) design with two replications.
View Article and Find Full Text PDFCooperative, Connected and Automated Mobility (CCAM) enabled by Connected and Autonomous Vehicles (CAVs) has potential to change future transport systems. The findings from previous studies suggest that these technologies will improve traffic flow, reduce travel time and delays. Furthermore, these CAVs will be safer compared to existing vehicles.
View Article and Find Full Text PDFObjective: A review of the clinical-pathologic characteristics and outcomes of biphasic polyps occurring in the female genital tract, not meeting the diagnostic criteria of Mullerian Adenosarcoma (MA).
Methods: An archival database search was run, after IRB approval, between 2001 and 2019, using terminology such as "Mullerian adenofibroma," "atypical Mullerian adenofibroma," "polypoid adenofibroma," and "atypical polyp with increased stromal cellularity." Two pathologists (JW and MRQ) reviewed all the retrieved cases and documented the morphologic features with particular emphasis on the presence of any features of Mullerian adenosarcoma.
The severity of vehicle-pedestrian crashes has prompted authorities worldwide to concentrate on improving pedestrian safety. The situation has only become more urgent with the approach of automated driving scenarios. The Responsibility-Sensitive Safety (RSS) model, introduced by Mobileye®, is a rigorous mathematical model developed to facilitate the safe operation of automated vehicles.
View Article and Find Full Text PDFIntroduction: Reclassification of HER2-negative breast cancers to HER2 low-level expression allowed targeted anti-HER2 therapy in about 60% of patients, improving outcome. The high recurrence rates and often dismal outcomes with current therapies of high-grade Mullerian carcinomas, offers opportunity to explore anti-HER2 therapies in the gynecologic tract carcinomas. We investigated HER2 low expression as currently defined in breast carcinomas.
View Article and Find Full Text PDFWhile histological diagnosis of Paget disease of vulva is mostly straightforward, identifying and confirming invasion can be challenging. Often invasion is accompanied by epidermal hyperplasia, marked inflammatory response and desmoplastic reaction. Diagnosis of invasion in Paget disease portends a poor outcome.
View Article and Find Full Text PDFRoad deaths globally have steadily climbed in recent years with the increase in motorisation. Yet in many economically developed countries they have actually fallen. Explanations for this reduction include the role of improved vehicle and highway design, better enforcement and the impact of the economic downturn, whilst there is also some evidence that microeconomic factors like changes in road fuel prices could be contributing to this situation.
View Article and Find Full Text PDFIn this study, a carbon-based adsorbent was developed from waste newspaper through pyrolysis at 800 °C to evaluate the removal efficiency of polycyclic aromatic hydrocarbons (Benzo[ghi]perylene (BghiP) and Indeno [1,2,3-cd] pyrene (IP)) from wastewater. The surface area of the developed adsorbent was estimated at 509.247mg which allowed the adsorption of the PAHs from wastewater.
View Article and Find Full Text PDFThis study explores the factors associated with passenger satisfaction on the UK railways. To uncover taste variation, the data was segmented into three homogeneous groups of passengers through a latent class ordered logit model, whereby the class allocation was based on observed personal and trip characteristics. The findings suggest that there is significant variation in the impact of service attributes on overall satisfaction across the segments, 'class a', 'class b' and 'class c'.
View Article and Find Full Text PDFLow-grade and high-grade serous carcinomas have unique clinical, morphological, underlying molecular alterations, and vastly different biologic behavior (Prat et al., 2018, Vang et al., 2009).
View Article and Find Full Text PDFPerivascular epithelioid cell tumors (PEComas), rare mesenchymal tumors with myomelanocytic differentiation, can be a diagnostic challenge, often requiring a panel of immunohistochemical markers. Preferentially expressed antigen in melanoma (PRAME) is a relatively new antigen with utility in diagnosing melanomas. This study aimed to survey PRAME expression patterns in the PEComa family of tumors and morphologic mimics.
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