Publications by authors named "Quasie Olga"

Background: In Ghana, leaves together with guava, pawpaw, and lime are processed into a decoction to treat fever. To encourage its usage, preclinical validation of the safety profile of the plant is required. The acute and subchronic toxicities of the conventional Soxhlet ethanolic leaves extract in Sprague-Dawley rats were investigated.

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Background: Medicinal plants represent a valuable source for new effective and safe antimicrobial drugs making them an alternative therapy. Existing antimicrobial agents are costly and mostly associated with possible side effects. The aim of the present study therefore, was to assess the antimicrobial property and phytochemical composition of hydroethanolic extract of Tapinanthus bangwensis leaves and its fractions.

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Background: A hydro ethanol extract of the stem bark of Holarrhena floribunda (HFE) has been shown to be effective in the management of acute inflammation. This study was to evaluate usefulness of the extract for the management of chronic inflammation in a murine model.

Methods: Arthritis was induced in Sprague-Dawley rats using Complete Freund's Adjuvant.

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Article Synopsis
  • - Eight new chemical compounds, including four limonoids, two steroids, one triterpenoid, and one lignan, were extracted from the stem barks of the Entandrophragma utile plant.
  • - The structures of these compounds were identified using advanced spectroscopic techniques like HRESIMS and 1D/2D-NMR.
  • - Bioactivity tests revealed that compounds 1, 6, and 7 can effectively reverse drug resistance in breast cancer cells, and compounds 5 and 6 showed moderate anti-inflammatory effects in activated macrophage cells.
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() is a plant commonly known as ginger lily, spiral ginger, or bush cane. It is reportedly used in traditional medicine practice (TMP) to treat and manage many ailments including diabetes mellitus, stomach ache, arthritis, inflammation, and gout. These purported ethnomedicinal uses have triggered many research studies on the plant to amass scientific evidence.

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Article Synopsis
  • - Seventeen new and unique limonoids were extracted from the stem barks of the Entandrophragma utile tree in Ghana, including nine previously unreported types with specific structural configurations (entanutilins C-K) and three other novel limonoids (entanutilins L-N).
  • - The chemical structures and configurations of these limonoids were determined using advanced analytical techniques like HRESIMS, NMR spectroscopy, CD exciton chirality, TDDFT/ECD calculations, and single-crystal X-ray diffraction.
  • - Some of the isolated compounds showed promising bioactivity, effectively overcoming drug resistance in certain cancer cells (MCF-7/DOX) at a safe concentration of 30 µM, with an
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Two new phragmalin-type limonoids orthoesters, encandollens A and B (1 and 2), were isolated from the stem barks of Entandrophragma candollei collected in Ghana. The structures of these compounds were elucidated on the basis of HR-ESI-MS, H and C NMR, HSQC, HMBC, and ROESY data. Compound 1 was a rare C-15 enolic acyl phragmalin-type limonoid orthoester.

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Ten new polyprenylated tetraoxygenated xanthones, monogxanthones A-J (1-10), together with eight known analogues (4b, 11-17) were identified from the roots of Hypericum monogynum. The structures of these new polyprenylated xanthones (1-10), a class of compounds rarely found in plants of the genus Hypericum, were elucidated by the interpretation of their HRESIMS, 1D and 2D NMR, and electronic circular dichroism data. Compounds 1 and 2 exhibited neuroprotective effects against corticosterone (Cort)-induced lesions of PC12 cells at concentrations of 6.

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Relying on characteristic double UV absorptions (210 and 270 nm), sixteen phragmalins with three types of enolic acyl substituents at C-15 were isolated directly from EtOH extracts of the seeds of Chukrasia tabularis A. Juss. Eight of these compounds possessed a C-15-acetyl phragmalin skeleton, and the basic carbon skeleton and absolute configuration of one of these was determined by NMR and X-ray diffraction analysis, while the structures of the other phragmalins were determined via NMR, HR-MS, and CD spectra.

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