Lncrna CASC11 aggravates diabetic nephropathy via targeting FoxO1.

Background: To explore the biological effects of CASC11 on aggravating diabetic nephropathy (DN) by regulating FoxO1 (forkhead transcription factor O1).

Methods: Serum levels of CASC11 and FoxO1 in DN patients were detected. The possibility of CASC11 in predicting the onset of DN was analyzed by depicting ROC curves.

Difference in oral microbiota composition between patients with stage 5 chronic kidney disease on hemodialysis and healthy controls.

Owing to the symbiotic relationship between the microbiota and the human body, the microbiome is considered a "second human genome". Microorganisms are inextricably associated with human diseases and can affect the host phenotype. In the present study, 25 female patients with stage 5 chronic kidney disease (CKD5) undergoing hemodialysis in our hospital and 25 healthy subjects were recruited.

Differences in gut microbiota structure in patients with stages 4-5 chronic kidney disease.

The gut microbiota can affect human metabolism, immunity, and other biologic pathways through the complex gut-kidney axis (GKA), and in turn participate in the occurrence and development of kidney disease. In this study, 39 patients with stage 4-5 chronic kidney disease (CKD) and 40 healthy individuals were recruited and 16S rDNA sequencing was performed to analyze the V3-V4 conserved regions of their microbiota. A total of 795 operational taxonomic units (OTUs) shared between groups or specific to each group were obtained, among which 255 OTUs with significant differences between the two groups were identified (<0.