Discovery of D8-03 as an Inhibitor of Intracellular Growth of .

is a Gram-negative facultative intracellular bacterial pathogen that is classified by the Centers for Disease Control and Prevention as a Tier 1 Select Agent. infection causes the disease tularemia, also known as rabbit fever. Treatment of tularemia is limited to few effective antibiotics which are associated with high relapse rates, toxicity, and potential emergence of antibiotic-resistant strains.

Predictive significance of glycolysis-associated lncRNA profiles in colorectal cancer progression.

Background: The Warburg effect is a hallmark characteristic of colorectal cancer (CRC). Despite extensive research, the role of long non-coding RNAs (lncRNAs) in influencing the Warburg effect remains incompletely understood. Our study aims to identify lncRNAs that may modulate the Warburg effect by functioning as competing endogenous RNAs (ceRNAs).

Metabolism-Related Prognostic Biomarkers, Purine Metabolism and Anti-Tumor Immunity in Colon Adenocarcinoma.

Background: Metabolic reprogramming provides a new perspective for understanding cancer. The targeting of dysregulated metabolic pathways may help to reprogram the immune status of the tumor microenvironment (TME), thereby increasing the effectiveness of immune checkpoint therapy. Colorectal cancer (CRC), especially colon adenocarcinoma (COAD), is associated with poor patient survival.

Mendelian randomization supports causality between gut microbiota and chronic hepatitis B.

Background: Observational studies have provided evidence of a close association between gut microbiota and the progression of chronic hepatitis B (CHB). However, establishing a causal relationship between gut microbiota and CHB remains a subject of investigation.

Methods: Genome-wide association study (GWAS) summary data of gut microbiota came from the MiBioGen consortium, while the GWAS summary data of CHB came from the Medical Research Council Integrative Epidemiology Unit (IEU) Open GWAS project.

"Fix and Click" for Assay of Sphingolipid Signaling in Single Primary Human Intestinal Epithelial Cells.

Capillary electrophoresis with fluorescence detection (CE-F) is a powerful method to measure enzyme activation in single cells. However, cellular enzymatic assays used in CE-F routinely utilize reporter substrates that possess a bulky fluorophore that may impact enzyme kinetics. To address these challenges, we describe a "fix and click" method utilizing an alkyne-terminated enzyme activation reporter, aldehyde-based fixation, and a click chemistry reaction to attach a fluorophore prior to analysis by single-cell CE-F.

Asymmetric Total Synthesis of Hetidine-Type C-Diterpenoid Alkaloids: (+)-Talassimidine and (+)-Talassamine.

Here, we report the first asymmetric total synthesis of (+)-talassimidine and (+)-talassamine, two hetidine-type C-diterpenoid alkaloids. A highly regio- and diastereoselective 1,3-dipolar cycloaddition of an azomethine ylide yielded a chiral tetracyclic intermediate in high enantiopurity, thus providing the structural basis for asymmetric assembly of the hexacyclic hetidine skeleton. In this key step, the introduction of a single chiral center induces four new continuous chiral centers.

Neighboring Hydroxyl Group-Assisted Allylboration and Lewis Acid-Mediated Carbonyl-Ene Reaction for Access to a Hapalindole Cyclohexane Core with Multiple Contiguous Stereogenic Centers.

A neighboring hydroxyl group-assisted allylboration of 3-indolyl ketones with γ,γ-disubstituted allylboronic acids is reported, affording various 3-indolyl-substituted homoallylic alcohols in good yields with excellent diastereoselectivies (up to >20:1 dr). The hydroxyl group not only played a vital role in the challenging allylboration but was elaborated for the subsequent construction of a hapalindole cyclohexane core by a highly diastereoselective Lewis acid-catalyzed carbonyl-ene reaction. In the overall process, four contiguous stereogenic centers including two quaternary stereogenic centers were installed.

Stereoselective Total Synthesis of Hetisine-type C -Diterpenoid Alkaloids: Spirasine IV and XI.

The first total synthesis of the architecturally complex hetisine-type heptacyclic C -diterpenoid alkaloids (±)-spirasine IV and XI is reported. The A/F/G/C tetracyclic skeleton with the challenging N-C6 and C14-C20 linkages was efficiently constructed by an intramolecular azomethine-ylide-based 1,3-dipolar cycloaddition with unusual regioselectivity. SmI -mediated free-radical addition to the arene moiety without prior dearomatization and a stereoselective intramolecular aldol reaction further enabled rapid access to the hetisine core, providing a bicyclo[2.

Bis[2-(3-pyridinio)benzimidazolium] di-mu-chloro-bis[trichlorocadmium(II)].

The title compound, (C12H11N3)2[Cd2Cl8], consists of two discrete 2-(3-pyridinio)benzimidazolium cations and one [Cd2Cl8]4- anion. The dimeric [Cd2Cl8]4- anion lies about an inversion centre and consists of two distorted [CdCl5] trigonal bipyramids which share a common edge. The two Cd atoms are each coordinated by two mu-Cl atoms and three terminal Cl atoms, with a Cd.

catena-Poly[[heptakis(dimethylformamide-kappaO)di-mu4-oxo-tetra-mu3-oxo-hexadeca-mu2-oxo-tetraoxolanthanum(III)octamolybdenum(IV)]-mu-sodium(I)].

The title compound, [NaLaMo(8)O(26)(C(3)H(7)NO)(7)](n), contains infinite chains of [Mo(8)O(26)](4-) units supporting dimethylformamide-coordinated La(III) cations and linked by Na(+) cations. The lanthanum center adopts a nine-coordinate geometry and the Na atom is sandwiched between two beta-[Mo(8)O(26)](4-) units.

catena-Poly[[[mu-pyridinium-3-carboxylato-bis[dioxomolybdenum(VI)]]-di-mu3-oxo] monohydrate].

A novel chain molybdenum compound, [[Mo2O6(C6H5NO2)].H2O]n, which was synthesized under hydrothermal conditions, consists of an infinite rail-like chain formed by molybdenum oxide units linked by zwitterionic nicotinic acid ligands. Each Mo atom is coordinated octahedrally by six O atoms and the MoO6 octahedra are linked to one another via edge-sharing to produce a zigzag polymeric chain, with nicotinic acid ligands located, alternately, on each side of the rail-like chain plane.

Structure and properties of a novel 3D straight-channel polyoxovanadate and an unexpected trimeric barbiturate obtained by hydrothermal reactions.

The hydrothermal reaction of NaVO(3).H(2)O, barbituric acid, NH(2)NH(2).2HCl, H(3)PO(4), and H(2)O gave a novel heteropolyoxovanadate Na(6)[(P(V)O(4))V(V)(6)V(IV)(12)O(39)](2).