Heterointerface Built Up by Ultrathin Amorphous MoO Conformal Coating Enables VO·6HO with Superior Properties for Aqueous Zinc Batteries.

Layered VO·6HO is a promising candidate for aqueous zinc batteries (AZBs) but with moderate electrochemical performances. Herein, the charge storage properties of VO·6HO are markedly improved by building up the heterointerface on its surface using amorphous molybdenum trioxide as the heteromaterial. The amorphous molybdenum trioxide functioning as the proton reservoir enables the proton-involved electrochemical reactions and induces the formation of a built-in electric field along the [001] orientation at the heterointerface constructed by the (001) plane of VO·6HO, which could provide new diffusion pathways and extra sites for ion storage.

A novel low-background nitroreductase fluorescent probe for real-time fluorescence imaging and surgical guidance of thyroid cancer resection.

Thyroid cancer always appears insidiously with few noticeable clinical symptoms. Due to its limitations, conventional ultrasound imaging can lead to missed or misdiagnosed cases. Surgery is still the primary treatment method of thyroid cancer, but removal of surrounding healthy tissues to minimize recurrence leads to overtreatment and added patient suffering.

Psathrosterols C-E, highly conjugated ergosterol derivatives from Psathyrella rogueiana with anti-inflammatory and immunosuppressive activity.

Three new ergosterols featuring with a highly conjugated ring system, psathrosterols C-E (1-3), have been isolated from the fungus Psathyrella rogueiana. The structures with the absolute configurations were elucidated by means of spectroscopic methods and single crystal X-ray diffraction. Compounds 1-3 exhibit inhibitory activity against NO production with IC values ranging from 8.

A novel NIR fluorescent probe for enhanced β-galactosidase detection and tumor imaging in ovarian cancer models.

The advancement of biological imaging techniques critically depends on the development of novel near-infrared (NIR) fluorescent probes. In this study, we introduce a designed NIR fluorescent probe, NRO-βgal, which exhibits a unique off-on response mechanism to β-galactosidase (β-gal). Emitting a fluorescence peak at a wavelength of 670 nm, NRO-βgal showcases a significant Stokes shift of 85 nm, which is indicative of its efficient energy transfer and minimized background interference.

A highly sensitive ratiometric fluorescent probe based on fluorescein coumarin for detecting hydrazine in actual water and biological samples.

Hydrazine (N H ) is a highly toxic and harmful chemical reagent. Fluorescent probes are simple and efficient tools for sensitive monitoring of N H enrichment in the environment, humans, animals, and plants. In this work, a ratiometric fluorescent probe (FP-1) containing coumarin was used for hydrazine detection.

A mitochondria-targeted rhodol fluorescent probe for imaging of hydrogen peroxide in living cells.

Hydrogen peroxide (HO) is a main member of reactive oxygen species (ROS) in cells that has a significant impact on various physiological and pathological processes of organisms. Here, we designed and synthesized a new type of fluorescent probe Rhodol-OAc for the specific detection of HO. The probe had good water solubility, high selectivity and sensitivity to HO, low cytotoxicity, excellent mitochondrial targeting ability, It was successfully applied in the imaging of exogenous and endogenous HO in living cells.

A novel ratiometric fluorescent probe for selective detection and imaging of HS.

In this work, a novel phenoxazine-based fluorescent probe BPO-N was developed to detect HS. The results showed that the probe had high selectivity and sensitivity toward HS, and its detection mechanism was based the ratio between green and red fluorescence signals; its detection limit was as low as 30 nM. The fluorescent imaging experiments further showed that the probe BPO-N could successfully detect endogenous and exogenous HS in living cells.

The Anti-Breast Cancer Potential of Bis-Isatin Scaffolds.

Aim: To develop novel anti-breast cancer agents and discuss the structure-activity relationship of bis-isatin scaffolds.

Background: Breast cancer is the most common invasive cancer and the second leading cause of cancer death in women after lung cancer. Bis-isatin scaffolds possess potential anti-breast cancer activity, and some of them such as Indirubin could induce cancer cells apoptosis via multiply mechanisms.

1,3,5-Triazine-azole Hybrids and their Anticancer Activity.

1,3,5-Triazine and azole can interact with various therapeutic targets, and their derivatives possess promising in vitro and in vivo anticancer activity. Hybrid molecules have the potential to enhance efficiency, overcome drug resistance and reduce side effects, and many hybrid molecules are under different phases of clinical trials, so hybridization of 1,3,5-triazine with azole may provide valuable therapeutic intervention for the treatment of cancer. Substantial efforts have been made to develop azole-containing 1,3,5-triazine hybrids as novel anticancer agents, and some of them exhibited excellent activity.

Design of a Nile red-based NIR fluorescent probe for the detection of hydrogen peroxide in living cells.

In this article, a novel fluorescent probe (NRBE) for detecting HO was developed using benzyl boronic ester as the HO-recognized group and Nile red as the matrix. The probe has several advantages, such as good selectivity, high sensitivity (LOD = 75 nM), good water solubility and emission in the near-infrared region (ex/em:585/670 nm). With the NRBE probe, the endogenous HO in human hepatocellular carcinoma cells BEL-7402, was detected, and the HO generated during the ischemia-reperfusion of the cells was imaged.

Two new illudane sesquiterpenoids and one new menthane monoterpene from cultures of Craterellus cornucopioides.

Two new illudane sesquiterpenoids, craterellins D and E (1 and 2), and one new menthane monoterpene, 4-hydroxy-4-isopropenyl-cyclohexanemethanol acetate (3), were isolated from cultures of Craterellus cornucopioides. Structures of 1-3 were elucidated on the basis of extensive spectroscopic analysis. Their cytotoxic activities on five tumor cell lines were evaluated.

A highly selective and sensitive rhodamine-derived fluorescent probe for detection of Cu.

A novel water-soluble and reversible fluorescent probe was designed and synthesized based on a rhodamine B derivative. It was used for detection of Cu in drinking water and in living cells with high sensitivity and excellent selectivity. The tested concentration range and the limit of detection (LOD) of the probe were 0-15.

Synthesis and application of thiol-functionalized magnetic nanoparticles for studying interactions of epirubicin hydrochloride with bovine serum albumin by fluorescence spectrometry.

A novel method was developed for studying the interaction between epirubicin hydrochloride (EPI) and bovine serum albumin (BSA) by fluorescence spectrometry. Fe O magnetic nanoparticles (MNPs) synthesized and functionalized with thiol group were employed for the immobilization and separation of target BSA in reaction solutions. The concentrations of the non-immobilized BSA and unbound EPI were obtained separately by fluorescence spectrometry.

A novel fluorescent probe for Cr(3+) based on rhodamine-crown ether conjugate and its application to drinking water examination and bioimaging.

A trivalent chromium (Cr(3+)) fluorescence probe (RhC) was designed and synthesized via Schiff base reaction based on rhodamine-crown ether conjugate. This probe displayed a favorable selectivity for Cr(3+) over a range of other common metal ions in DMF/H2O (3:7, v/v; PBS buffer 50 mmol L(-1); pH=6.8) solution, leading to prominent fluorescence "OFF-ON" switching of the rhodamine fluorophore.