Multi-instance learning based artificial intelligence model to assist vocal fold leukoplakia diagnosis: A multicentre diagnostic study.

Objective: To develop a multi-instance learning (MIL) based artificial intelligence (AI)-assisted diagnosis models by using laryngoscopic images to differentiate benign and malignant vocal fold leukoplakia (VFL).

Methods: The AI system was developed, trained and validated on 5362 images of 551 patients from three hospitals. Automated regions of interest (ROI) segmentation algorithm was utilized to construct image-level features.

Pan-cancer analysis of the prognostic and immunological role of GJB2: a potential target for survival and immunotherapy.

Background: GJB2 plays an essential role in the growth and progression of several cancers. However, asystematic pan-cancer analysis of GJB2 is lacking. Therefore, in this study, we performed a comprehensive pan-cancer analysis to determine the potential role of GJB2 in prognostic prediction and cancer immunotherapy response.

Efficacy and safety of triamcinolone acetonide in the prevention of esophageal stricture after endoscopic submucosal dissection: a meta-analysis.

Aim: The role of triamcinolone acetonide (TA) in the prevention of esophageal stricture is not well established. This meta-analysis aimed to evaluate its safety and efficacy for the prevention of esophageal stricture after endoscopic submucosal dissection (ESD).

Methods: A comprehensive search was performed in electronic databases including PubMed, the Cochrane Library, Embase for possible controlled studies.

Efficacy of EGFR-TKI sequential therapy in patients with exon 19 insertion-positive non-small-cell lung cancer: A case report.

Background: Insertions in exon 19 in the epidermal growth factor receptor gene (EGFR) is a rarely seen mutation in non-small cell lung cancer. These patients have been effectively treated with sequential EGFR tyrosine kinase inhibitors (TKIs).

Case Summary: Here, we presented a case of non-small cell lung cancer, stage IIIB, with exon 19 insertion mutation as detected in the right lower lobe by next-generation sequencing.

Submucosal oesophageal squamous cell carcinoma with lymph node metastasis: a case report and literature review.

Background: Submucosal oesophageal squamous cell carcinoma is a quite infrequent and special type of oesophageal cancer. Its endoscopic manifestations are similar to those of submucosal oesophageal lesions, so it is easily ignored or misdiagnosed. Thus, the exact and timely diagnosis of oesophageal subepithelial lesions (SELs) is crucial.

Synchronous multiple carcinoma with small intestine and pulmonary neuroendocrine involvement: A case report.

Rationale: In clinical work, neuroendocrine synchronous multiplicity carcinoma was relatively rare. Most were confirmed by the pathological diagnosis of a certain part of the body combined with the imaging of the whole body, while cases that had both pathological and immunohistochemistry diagnosis were few.

Patient Concerns: A patient who presented with abdominal pain visited our hospital, and was diagnosed with lesions in both the small intestine and lung.