Publications by authors named "Quanli Wu"

Background: Septic shock is the most serious complication of sepsis, with more secure and efficient biomarkers urgently needed. Systemic immune-inflammation index (SII) and serum procalcitonin (PCT) show involvement in predicting septic shock prognosis.

Objective: Herein, we explored the clinical value of the SII-PCT combination in the short-term prognosis of septic shock patients.

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The diseases caused by two pathological processes, thrombosis, and thromboembolism, are clinically known as thrombotic diseases, which seriously threaten human life and health, and their incidence rate is the highest among various diseases. Research on thrombotic diseases is one of the focuses and hotspots of contemporary medical research. Nanomedicine is a new branch of nanotechnology used in the medical field, and nanomaterials are widely used in medical imaging and drug delivery to help diagnose and treat major diseases such as cancer.

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Pigeon breed resources provide a genetic model for the study of phenomics. The pectoral muscles play a key role for the meat production performance of the meat pigeon and the athletic ability of the High flyers. Euro-pigeons and Silver King pigeons are commercial varieties that exhibit good meat production performance.

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To explore the molecular mechanism of Georgi in treating gastric cancer by network pharmacological analysis and molecular docking. Taking Georgi as the object, the active components and corresponding potential drug targets in Georgi were obtained from the database of TCM Pharmacological System Analysis Platform (TCMSP). GeneCards/OMIM/DrugBank and other databases were used to collect gastric cancer-related genes, and the obtained genes were intersected with drug targets to obtain the target genes of Georgi on gastric cancer.

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Ischemic stroke resulting from atherosclerosis (particularly in the carotid artery) is one of the major subtypes of stroke and has a high incidence of death. Disordered lipid homeostasis, lipid deposition, local macrophage infiltration, smooth muscle cell proliferation, and plaque rupture are the main pathological processes of atherosclerotic ischemic stroke. Hepatocytes, macrophages, endothelial cells and vascular smooth muscle cells are the main cell types participating in these processes.

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Objective: To screen for immune genes that play a major role in Kawasaki disease and to investigate the pathogenesis of Kawasaki disease through bioinformatics analysis.

Methods: Kawasaki disease-related datasets GSE18606, GSE68004, and GSE73461 were downloaded from the Gene Expression Omnibus database. Three microarrays were integrated and standardized to include 173 Kawasaki disease samples and 101 normal samples.

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Objective: To construct recombination eukaryote expression plasmid for human parathyroid hormone (PTH) gene, assay PTH expression and biological activity after transfection in vitro and evaluate gene therapy effect on hypoparathyroidism (HPT).

Methods: (1) PTH gene was amplified from human embryonic parathyroid gland tissue, and plasmid pcDNA3.1-PTH-GFP (pcDPG) was constructed by TOPO recombination technique.

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