Miliutine C methyl ester, a new drimane sesquiterpene and bioactive alkaloids from the stems of .

Previous results from the our research group have isolated numerous compounds, including novel ones, but the anticancer activity of has not been demonstrated. In this study, from the most active ethyl acetate extract of the stems of , seven compounds were isolated and determined structures, including a new drimane sesquiterpenoid compound named miliutine C methyl ester () and three bioactive alkaloids (-). These three alkaloids (-) exhibited strong anticancer activities against various cancer cell lines such as MCF-7, HepG2, HeLa, NCI H460 and normal fibroblasts.

Miliutine A acid, a new cyclofarnesane sesquiterpene from the stems of .

Six compounds were isolated from the ethyl acetate extract of the stems of , including miliutine A acid (), a new cyclofarnesane sesquiterpenoid; miliutine B methyl ester (), a cyclofarnesane sesquiterpenoid which was determined the absolute configuration for the first time and four known phenol derivatives (-). NMR spectroscopic and mass spectrometry were used for identifying relative configurations. The assignments of the absolute configurations were determined based on Electronic Circular Dichroism (ECD) and NOESY spectra analysis.

Two new halogenated sesquiterpene lactones from .

Two new sesquiterpene lactones, laurenolide A () and laurenolide B (), along with six known compounds, palmitic acid (), (,)-hexahydrofarnesyl acetone (), -phytol acetate (), cholesterol (), cholesteryl acetate (), cholesteryl heptadecanoate () were isolated from . The chemical structures of all compounds were elucidated by 1D and 2D-NMR spectroscopy and HR-ESI-MS analysis as well as compared with data in the literature. The petroleum ether, chloroform, ethyl acetate, methanol extracts and compounds , were tested for the inhibition of two cancer cell lines MCF-7, NCI-H460 and they showed weak or none activities.

Two new sesquiterpenes from the stems of .

From the ethyl acetate extract of the stems of , seven compounds (-) were isolated, including two new compounds such as mivelutina A acid (), mivelutina B acid () and one known compound mivelutina B methyl ester (). For this NMR data were not known previously. Their relative structures were elucidated based on NMR spectroscopic analysis.

A new lignan from the flowers of L. (Malvaceae).

From MeOH-soluble fraction of the flowers of (Malvaceae), one new lignan, (+)-4--methyl-5'-methoxy-secoisolariciresinol (), together with four known compounds (-) were isolated. The structures were elucidated based on NMR spectroscopic analysis. The absolute configuration of was determined based on the Cotton effects in the CD spectrum.

Chemical constituents of Geum urbanum L. roots.

A new dehydrodigallic acid derivative (1), along with 19 known compounds, including 6 phenolic derivatives, 2 steroids and 11 triterpenoids were isolated from the ethanol extract of the root of Geum urbanum. Herein, there is the first report of steroid and triterpene in Geum urbanum. The purified metabolites were characterised by NMR spectroscopic and mass spectrometric analyses.

Three new iridoid glucoside salts from Hedyotis tenelliflora Growing in Vietnam.

Three new sodium salts of iridoid acids, deacetylasperulosidic acid sodium salt (1), teneoside D (2), and teneoside E (3) were isolated from the leaves of Hedyotis tenelliflora Blume (Rubiaceae), together with seven known iridoids, 6alpha-hydroxygeniposide (4), 6beta-hydroxygeniposide (5), 6-O-methyldeacetylasperulosidic acid methyl ester (6), 6-O-methylscandoside methyl ester (7), 6alpha-methoxygeniposidic acid (8), daphylloside (9), and mollugoside methyl ester (10). Their chemical structures were elucidated by 1D and 2D NMR spectroscopy, as well as HR-ESI-MS analysis.

Cytotoxic activity of new phenolic compounds from Vietnamese Caesalpinia sappan.

Two new phenolic compounds, caesalpiniaphenols G-H (1 and 2), were isolated from Vietnamese Caesalpinia sappan heartwood. The chemical structures were established mainly by extensive spectroscopic studies and chemical evidence. Compounds 1 and 2 showed potent inhibitory activity against HL-60 cancer cell lines with respective IC50 values of 16.

Wedelolides A and B: novel sesquiterpene delta-lactones, (9R)-eudesman-9,12-olides, from Wedelia trilobata.

Two new sesquiterpene lactones, wedelolides A (1) and B (2), were isolated by bioassay-guided fractionation from the leaves of Wedelia trilobata, together with known trilobolides 6-O-isobutyrate (3) and 6-O-methacrylate (4). The compounds 1 and 2 were the first examples of an unprecedented framework: a novel sesquiterpene delta-lactone, (9R)-eudesman-9,12-olide. The structures of the antimalarial wedelolides A (1) and B (2) were determined on the basis of MS and 2D NMR spectral analysis.

Schiff bases of gossypol: an NMR and DFT study.

Schiff bases of gossypol with benzylamine, methylamine, 4-aminoacetophenone and 4-fluoroaniline have been synthesized and characterized by NMR spectroscopy. All the Schiff bases of gossypol are in the enamine form according to (3)J(HC,NH) and (1)J(N,H) coupling constants. The spectra are basically unchanged by change of solvent (CD(2)Cl(2), THF-d(8) and CD(3)OD) and by variation of temperature.