Publications by authors named "Quan-gang Xu"
Leber's hereditary optic neuropathy companied with multiple-related diseases.
Front Hum Neurosci
November 2022
Objective: To elucidate the clinical, radiologic characteristics of Leber's hereditary optic neuropathy (LHON) associated with the other diseases.
Materials And Methods: Clinical data were retrospectively collected from hospitalized patients with LHON associated with the other diseases at the Neuro-Ophthalmology Department at the Chinese People's Liberation Army General Hospital (PLAGH) from December 2014 to October 2018.
Results: A total of 13 patients, 24 eyes (10 men and 3 women; mean age, 30.
Article Synopsis
- - The study aims to explore the relationship between final best-corrected visual acuity (BCVA) and optic nerve structure loss in different age groups of patients with optic neuritis (ON).
- - It compares data from 130 ON patients, finding that younger patients (0-18 years) have better visual outcomes and fewer relapses compared to adults, with significant correlations between BCVA and measurements of optic nerve fibers and macular layers.
- - The results suggest that pediatric ON has the best prognosis, while young adults show strong linear correlations between vision and structural loss, indicating that pRNFL and mRGCL metrics could help predict visual outcomes in various age groups.
Article Synopsis
- Ethambutol-induced optic neuropathy (EON) is a known eye issue in tuberculosis patients using ethambutol, and this study looked at mitochondrial mutations related to EON.
- Out of 47 patients evaluated, 46.8% had mutations, with those carrying mutations presenting at a younger average age of 27.5 years compared to 48 years for those without mutations.
- The study found that patients with mitochondrial mutations had a higher prevalence of optic disc hyperemia and worse vision prognosis, indicating that these mutations may increase sensitivity to ethambutol's toxic effects.
Background: Brucellosis is one of the most common zoonoses worldwide, causing direct losses to the livestock industry and threatening human health. Little is known about the status and factors affecting farmers' private investment in the prevention and control of sheep brucellosis in China.
Methodology/principal Findings: From April to October 2017, a cross-sectional, house-based study was conducted in 7 Chinese provinces.
Purpose: To evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO) with ON eyes (NMO-ON) compared with an AQP4-Ab seronegative ON (AQP4-Ab-/ON) cohort using optical coherence tomography (OCT).
Methods: We recruited 109 patients with ON (161 eyes) and 47 healthy controls. All patients with ON were subdivided into three subcohorts: 37 patients (54 eyes) with AQP4-Ab+/ON, 45 patients (65 eyes) with AQP4-Ab-/ON and 27 patients (42 eyes) with NMO-ON.
Article Synopsis
- CADASIL has been observed in various regions, but there is limited data on its prevalence in the Chinese population.
- A study of 52 Chinese CADASIL patients revealed that symptoms typically onset around age 42, with common issues including strokes, hemorrhages, migraines, and dementia.
- The findings indicate similarities with CADASIL patients worldwide, but with higher cases of intracerebral hemorrhage and vertigo in Chinese patients, and genetic mutations mainly found in exons 3 and 4.
Objective: To investigate the changes of CCR7 and CD45RA expression after blocking of the potassium channel Kv1.3 in myelin specific CD4 T lymphocytes and the relation thereof with multiple sclerosis(MS).
Methods: Peripheral blood mononuclear cells were isolated from 15 activated MS patients, 15 INF-beta-1b treated MS patients, and 15 normal controls, CD4+ T lymphocytes were isolated using positive selection method with anti-CD4-coated magnetic beads.
[R1239H mutation of CACNA1S gene in a Chinese family with hypokalaemic periodic paralysis].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
June 2006
Objective: Mutation screening was performed to a Chinese family with hypokalaemic periodic paraiysis(HOKPP) for locating the corresponding mutations of gene and for specifying the clinical features associated with mutations.
Methods: The cilnical features of patients from HOKPP family were summurized. Techniques of target exon PCR and direct sequencing were used to screen the mutation in CACNA1S and SCN4A genes in all numbers of the family.
[The mutation R672H in SCN4A gene exists in Chinese patients with hypokalaemic periodic paralysis].
Zhonghua Yi Xue Za Zhi
March 2006
Objective: Mutation screening was performed on two Chinese families with HOKPP to locat the corresponding mutations and to specify the clinical features associated with the mutation.
Methods: Target-exon PCR and direct sequencing were used to screen mutation in the CACNA1S and SCN4A gene of all numbers of the two families. The clinical features of patients were summary.