Publications by authors named "Quan-chang Tan"
Article Synopsis
- Cervical spine fractures often lead to severe spinal cord injuries, which carry a high risk of death, particularly in the first year after the injury. Understanding mortality rates can aid in decision-making for patients and families.
- The study included 450 patients and revealed that surgical treatment lowers the immediate death risk, especially when performed early. Survival rates improved from 73.3% at baseline to 88.0% after two years.
- Conditional nomograms were developed to predict survival probabilities at various milestones (baseline, 6 months, and 12 months), showing strong performance in forecasting outcomes for patients post-injury.
Article Synopsis
- Polymethyl methacrylate (PMMA) bone cement is widely used in orthopedic surgery but has limitations like shrinkage, heat injury, and low bioactivity.
- Researchers developed a new material, expandable P(MMA-AA-St), which reduces shrinkage but lacks strong biomechanical properties, leading to the addition of graphene oxide (GO) for improvement.
- The modified composite, PGBCs, showed enhanced strength, water absorption, and cell compatibility, with better outcomes in rabbit bone defect studies, indicating its potential as an effective biomaterial for implants.
Revision surgery (RS) is a necessary surgical intervention in clinical practice to treat spinal instrumentation-related symptomatic complications. Three constructs with different configurations have been applied in RS. One distinguishing characteristic of these configurations is that the revision rods connecting previous segments and revision segments are placed alongside, outside, or inside the previous rods at the level of facetectomy.
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- This study compared different surgical constructs for revision surgery on adjacent segment disease, focusing on how each method affects spinal stability and pressure on intervertebral discs.
- A finite element model was used to analyze four different constructs after primary surgery, looking at factors like range of motion and stress distribution.
- Results showed that implant-preserving methods gave similar biomechanical outcomes as traditional implant-replacing methods, with one construct (Construct B) suggested as the best option for being less invasive and easier to handle.
Spinal instrumented rod migrating from the surgical site to another remote site in the body is rare. Some cases result in organ or blood vessel injury. Most reported cases were asymptomatic until the finally injuries were generated.
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- The study evaluated a new connector rod's mechanical properties for preserving implants during revision surgery for adjacent segment disease, compared to traditional rod constructs that replace implants.
- Results showed that the connector rod performed similarly mechanically but resulted in significantly less surgical time and blood loss, with a lower infection rate compared to the traditional method.
- The connector rod led to better early postoperative results in pain and disability scores, confirming its safety and potential for reducing surgical trauma and costs.
Extracellular matrix loss is one of the early manifestations of intervertebral disc degeneration. Stem cell-based tissue engineering creates an appropriate microenvironment for long term cell survival, promising for NP regeneration. We created a decellularized nucleus pulposus hydrogel (DNPH) from fresh bovine nucleus pulposus.
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- The study aimed to find the best amount of polymethylmethacrylate (PMMA) to use for enhancing a new type of fenestrated pedicle screw (FPS) designed for osteoporotic vertebrae and how PMMA distribution impacts screw strength.
- Two FPS designs were tested, one with equal diameter perforations and another with tapered perforations, across 28 human cadaver vertebrae, evaluating factors like cement distribution and pullout strength.
- Results showed that while increasing PMMA volume improved strength and altered cement distribution, the tapered design led to better PMMA anchoring and a lower risk of leakage, especially at higher volumes.
Article Synopsis
- The study evaluated a new total cervical prosthesis (TCP) designed for single-level cervical subtotal corpectomy in a model using 12 adult Shannxi goats.
- The research aimed to assess both the radiologic and histological characteristics of the TCP, which offers a viable alternative to existing cervical disk replacements that are not suitable for subtotal corpectomy procedures.
- Results indicated successful implantation with no complications, preservation of motion in nearby vertebral segments, and positive signs of bone integration with the prosthesis, showing potential for effective stability after surgery.
Article Synopsis
- * In an experiment with 96 male BALB/c mice, telmisartan was tested for its effect on femur fracture healing over periods of 2, 5, and 10 weeks using various analysis methods including X-ray and biomechanical testing.
- * Results revealed that telmisartan significantly enhanced callus formation, bone strength, and improved the microstructure of the healing bone, likely through increased cell proliferation and blood vessel formation.