Psathrosterols C-E, highly conjugated ergosterol derivatives from Psathyrella rogueiana with anti-inflammatory and immunosuppressive activity.

Three new ergosterols featuring with a highly conjugated ring system, psathrosterols C-E (1-3), have been isolated from the fungus Psathyrella rogueiana. The structures with the absolute configurations were elucidated by means of spectroscopic methods and single crystal X-ray diffraction. Compounds 1-3 exhibit inhibitory activity against NO production with IC values ranging from 8.

The Anti-Breast Cancer Potential of Bis-Isatin Scaffolds.

Aim: To develop novel anti-breast cancer agents and discuss the structure-activity relationship of bis-isatin scaffolds.

Background: Breast cancer is the most common invasive cancer and the second leading cause of cancer death in women after lung cancer. Bis-isatin scaffolds possess potential anti-breast cancer activity, and some of them such as Indirubin could induce cancer cells apoptosis via multiply mechanisms.

1,3,5-Triazine-azole Hybrids and their Anticancer Activity.

1,3,5-Triazine and azole can interact with various therapeutic targets, and their derivatives possess promising in vitro and in vivo anticancer activity. Hybrid molecules have the potential to enhance efficiency, overcome drug resistance and reduce side effects, and many hybrid molecules are under different phases of clinical trials, so hybridization of 1,3,5-triazine with azole may provide valuable therapeutic intervention for the treatment of cancer. Substantial efforts have been made to develop azole-containing 1,3,5-triazine hybrids as novel anticancer agents, and some of them exhibited excellent activity.

Two new illudane sesquiterpenoids and one new menthane monoterpene from cultures of Craterellus cornucopioides.

Two new illudane sesquiterpenoids, craterellins D and E (1 and 2), and one new menthane monoterpene, 4-hydroxy-4-isopropenyl-cyclohexanemethanol acetate (3), were isolated from cultures of Craterellus cornucopioides. Structures of 1-3 were elucidated on the basis of extensive spectroscopic analysis. Their cytotoxic activities on five tumor cell lines were evaluated.