Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO Production.

Endothelial progenitor cells (EPCs) contribute to the endogenous endothelial repair program during hypercholesterolemia. EPC count and migratory and proliferative capacities remain unchanged in the premenopausal female with hypercholesterolemia. However, the changes of count and activity of circulating EPCs in the hypercholesterolemic postmenopausal females are unknown.

[Analysis of glucose levels and the risk for coronary heart disease in elderly patients in Guangzhou Haizhu district].

Objective: To investigate the prevalence of diabetes and prediabetes and their association with the risk for coronary heart disease (CHD) in elderly residents in Haizhu District of Guangzhou.

Methods: Stratified random sampling was employed to select a total of 1800 resident aged 50 years or older in the region. The fasting fingertip blood glucose>5.

[Value of biochemical marker detection in risk stratification in patients with acute coronary syndrome].

Objective: To assess the value of biochemical marker detection in risk stratification in hospitalized patients with acute coronary syndrome (ACS).

Methods: A total of 264 consecutive patients (180 male and 84 female patients) admitted for complaint of chest tightness or/and pain were evaluated for a decision of coronary angiography (CAG) within 24 h after admission. The patients were divided into two groups to receive emergency or elective CAG.

[Peripheral dendritic cell subpopulation changes in patients with coronary artery disease].

Objective: To compare the peripheral dendritic cell subpopulation changes in patients with or without coronary artery disease.

Methods: A total of 60 patients with angiographic documented coronary artery disease (CAD) were recruited in this study, including 20 cases with acute myocardial infarction (AMI group), 20 cases with unstable angina(UA group) and 20 patients with stable angina (SA group). Eleven patients with chest pain and without coronary stenosis served as chest pain control (CPS group).

[Effect of enalapril on diabetic rat myocardial ultrastructure].

Objective: To observe the changes in the myocardial ultrastructure of diabetic rats and the effect of enalapril treatment.

Methods: Male Wistar rats were divided into 3 groups, namely the control group, diabetic group and enalapril intervention group. Diabetes was induced with peritoneal injection of streptozotocin in the latter 2 groups, and in enalapril group, the rats were treated with enalapril at the daily oral dose of 2 mg/kg for 1, 3 and 5 months after streptozotocin injection.

[Changes of CD4+CD28- T cell and CD4+CD25+ regulatory T cell subsets in patients with coronary heart disease].

Objective: To investigate the changes of CD4(+)CD28(-) T cell and CD4(+)CD25(+) regulatory T cell (Treg) subsets in patients with coronary artery disease (CAD).

Methods: Twenty-eight patients with angiographically established CAD were recruited in this study, including 16 with unstable angina (UA group) and 12 with stable angina (SA group). Eleven patients with chest pain syndrome served as the control group.

[Mechanism of urotensin II-stimulated adrenomedullin secretion in human vascular endothelial cells].

Objective: To study the mechanism of urotensin II(U II)-stimulated adrenomedullin secretion in human vascular endothelial cells.

Methods: In cultured human vascular endothelial cells (HEVCs), different concentrations of U II was used to stimulate the secretion of Adm, and different inhibitors were used to study the changes in the secretion after block of different signal transduction pathways. The contents of Adm in the medium were detected with radioimmunoassay.

[Short-term effect of percutaneous transluminal coronary angioplasty with stent implantation in treating myocardial infarction with severe pump failure].

Objective: To evaluate the short-term therapeutic effect of percutaneous transluminal coronary angioplasty (PTCA) with stent implantation in the treatment of myocardial infarction with severe pump failure.

Methods: The clinical data of 73 patients receiving PTCA and stent implantation for myocardial infarction with severity pump failure were analyzed and grouped according the occurrence of complications, degree of the vascular lesions and the complexity of the surgical procedures. Preoperative and postoperative ventricular ejection fractions (LVEF) were compared in each case.

[Detection of high-sensitivity C-reactive protein and total cholesterol/high-density lipoprotein cholesterol ratio for diagnosis of coronary artery disease].

Objective: To study the value of detecting high-sensitivity C-reactive protein (hs-CRP) combined with determination of total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) in the diagnosis of coronary artery disease (CHD).

Methods: A total of 240 patients with documented CHD and 40 healthy subjects were enrolled in this study for measurement of serum concentrations of hs-CRP, TC and HDL-C.

Results: The concentration of hs-CRP and TC/HDL-C ratio was significantly higher in CHD patients than in the control subjects (P<0.

[Clinical study of plasma urotensin II in patients with coronary heart disease].

Objective: To investigate the changes in plasma urotensin II(U II) expression levels in patients with coronary heart disease (CHD).

Methods: Plasma U II levels in 50 CHD patients with coronary stenosis indicated by coronary angiography and 20 healthy subjects were determined by radio immunoassay.

Results: Venous plasma U II levels were significantly lowered in CHD patients in comparison with the healthy subjects (1.

Changes of plasma adrenomedullin and proadrenomedullin N-terminal 20 peptide concentrations in patients with heart failure.

Objective: To study the changes in plasma adrenomedullin (ADM) and proadrenomedullin N-terminal 20 peptide (PAMP) concentrations and their clinical significance in the pathological process of congestive heart failure (CHF).

Methods: Plasma ADM and PAMP concentrations in 45 patients with CHF (according to the functional classification of New York Heart Association, NYHA) and 20 control subjects were measured by specific radioimmunoassay.

Results: Plasma ADM concentrations were 51.

[Changes in plasma levels of adrenomedullin and cyclic adenosine monophosphate and their interrelation in patients with chronic heart failure].

Objective: To investigate the changes in plasma levels of adrenomedullin (ADM) and cyclic adenosine monophosphate (cAMP) in patients with chronic heart failure (CHF) in an attempt to understand the role of ADM in the occurrence and development of CHF.

Methods: The plasma levels of cAMP and ADM were measured by radioimmunoassay in 45 patients with CHF (including 10 of NYHA classII, 15 of class III, and 20 of class IV) and 20 healthy controls respectively.

Results: Plasma ADM and cAMP levels significantly increased in patients of NYHA class II, III, and IV as compared with the healthy controls (P<0.