A suture technique combining annulus fibrosis with posterior longitudinal ligament for lumbar disc herniation under endoscopy.

Purpose: To investigate the clinical feasibility, efficacy and safety of a suture technique combining annulus fibrosus with posterior longitudinal ligament under full endoscopy in patients with lumbar disc herniation.

Methods: Retrospective case-control study. A total of 412 patients with lumbar disc herniation treated in our hospital from January 2020 to November 2022 were enrolled and analyzed.

Virological and Immunological Characteristics of HBeAg-Positive Chronic Hepatitis B Patients With Low HBsAg Levels.

Background: HBeAg-positive chronic hepatitis B (CHB) with low HBsAg levels represents a relatively rare serological pattern and is closely associated with the severity of liver disease. However, the underlying mechanisms in such cases remain largely unclear.

Methods: Treatment-naïve HBeAg-positive CHB patients with low HBsAg levels in China were enrolled and analysed.

Poly l-Lactic Acid Nanofiber Membrane Effectively Inhibits Liver Cancer Cells Growth and Prevents Postoperative Residual Cancer Recurrence.

Electrospun nanocarrier systems, widely employed in the medical field, exhibit the capability to encapsulate multiple drugs and mitigate complications. Doxorubicin hydrochloride (DOX) represents a frequently utilized chemotherapeutic agent for liver cancer patients. Sodium bicarbonate (SB) serves to neutralize the acidic tumor microenvironment, while ibuprofen (IBU) attenuates inflammatory factor production.

Construction of novel magnetic systems for cancer immunotherapy via cancer-immunity cycle circuits.

The tumor microenvironment (TME) is enriched with immunosuppressive factors that inhibit the recruitment and activation of dendritic cells (DCs), thereby reducing the efficacy of tumor immunotherapy. To address this challenge, we propose an innovative strategy involving the sequential administration of MCM magnetic nanoparticles carrying PROTAC drugs (MCM/ARV) and M-BMDCs in the TEM. This approach not only replenishes DCs in the TEM, but also increases antigen uptake through the attraction between the magnetic particles and promotes DC activation and antigen presentation, thus continuously enhancing the tumor immune cycle.

Radiative cooling: arising from practice and in turn serving practice.

Radiative cooling, as a renewable cooling technology, is expected to mitigate growing global warming. However, the barrier when promoting radiative cooling from the laboratory to practice is still a blind spot and needs to be discussed right now. Here, on the basis of review for brief history, we propose a developing thread that the studies on radiative cooling arise from practice and in turn serves practice at the end.

Advanced aspects of acetogens.

Acetogens are a diverse group of anaerobic bacteria that are capable of carbon dioxide fixation and have for long fascinated scientists due to their unique metabolic prowess. Historically, acetogens have been recognized for their remarkable ability to grow and to produce acetate from different one-carbon sources, including carbon dioxide, carbon monoxide, formate, methanol, and methylated organic compounds. The key metabolic pathway in acetogens responsible for converting these one-carbon sources is ́the Wood-Ljungdahl pathway.

Cobalt Incorporation Promotes CO Desorption from Nickel Active Sites Encapsulated by Nitrogen-Doped Carbon Nanotubes in Urea-Assisted Water Electrolysis.

The potential application prospects of urea-assisted water electrolysis toward hydrogen production in renewable energy infrastructure can effectively alleviate energy shortages and environmental pollution caused by rich urea wastewater. It is of prominent significance that adjusting the CO desorption of nickel-based electrocatalysts can overcome the slow reaction kinetics for urea oxidation reaction (UOR) to achieve exceptional catalytic activity. In this work, cobalt (Co) metal doping is employed to boost the UOR performance of nitrogen-doped carbon nanotubes encapsulating nickel nanoparticle electrocatalysts (Ni@N-CNT).

In-situ Reduced CuN Nanocrystals Enable High-Efficiency Ammonia Synthesis and Zinc-nitrate Batteries.

Nitrate reduction reaction (NORR) involves an 8-electron transfer process and competes with the hydrogen evolution reaction process, resulting in lower yields and Faraday efficiency (FE) in the process of NH synthesis. Especially, Cu-based catalysts (Cu and Cu) have been investigated in the field of NORR due to the energy levels of d-orbital and the least unoccupied molecular orbital (LUMO) π* of nitrate's orbital. Based on the above, we synthesized a Cu-based compound containing CuN (Cu) through a simple one-step pyrolysis method, applied it to electrocatalytic NORR, and tested the performance of the Zn-NO battery.

Two-Dimensional Topological Platinum Telluride Superstructures with Periodic Tellurium Vacancies for Efficient and Robust Catalysis.

Defect engineering in the inherently inert basal planes of transition metal dichalcogenides (TMDs), involving the introduction of chalcogen vacancies, represents a pivotal approach to enhance catalytic activity by exposing high-density catalytic metal single-atom sites. However, achieving a single-atom limit spacing between chalcogen vacancies to form ordered superstructures remains challenging for creating uniformly distributed high-density metal single-atom sites on TMDs comparable to carbon-supported single-atom catalysts (SACs). Here we unveil an efficient TMD-based topological catalyst for hydrogen evolution reaction (HER), featuring high-density single-atom reactive centers on a few-layer (7 × 7)-PtTe superstructure.

Anodization-Processed Colored Radiative Thermoregulatory Film.

Colored radiative thermal management materials (RTMM) not only provide superior thermoregulatory performance but also satisfy aesthetic requirements. However, the complexity of the preparation procedures and constrained color selection have hindered their widespread adoption. Here, we presented a facile one-step anodizing strategy for fabricating colored dual-mode RTMM based on titanium film (Ti) and P(VDF-HFP) with mid-infrared (MIR) emissivities of 0.

The effect of pallidal stimulation on sleep outcomes and related brain connectometries in Parkinson's disease.

Sleep difficulties affect up to 98% of Parkinson's disease (PD) patients and are often not well treated. How globus pallidus internus (GPi)-DBS could help is less understood. We retrospectively analyzed sleep outcomes in 32 PD patients after GPi-DBS with a two-year follow-up.

Nicotinic Signaling Stimulates Glucagon Secretion in Mouse and Human Pancreatic α-Cells.

Smoking is widely regarded as a risk factor for type 2 diabetes because nicotine contributes to insulin resistance by desensitizing the insulin receptors in muscle, liver, or fat. Little is known, however, about the immediate regulation of islet hormonal output by nicotine, an agonist of ionotropic cholinergic receptors. We investigated this by imaging cytosolic Ca2+ dynamics in mouse and human islets using confocal microscopy and measuring glucagon secretion in response to the alkaloid from isolated mouse islets.

Targeted sonodynamic therapy induces tumor cell quasi-immunogenic ferroptosis and macrophage immunostimulatory autophagy in glioblastoma.

In this study, we demonstrated the mechanism of a glioblastoma (GBM)-targeted sonodynamic therapy (SDT) strategy employing platelets loaded with a sonosensitizer based on functionalized boron nitride nanoparticles carrying chlorin e6 (BNPD-Ce6). In the in vitro study, we first found that the BNPD-Ce6-mediated sonodynamic action (SDA) induced remarkable viability loss, DNA damage, and cell death in the GBM cells (GBCs) but not macrophages. Surprisingly, the SDA-exposed GBCs displayed a ferroptotic phenotype while the SDA-exposed macrophages underwent immuno-stimulatory autophagy and potently potentiated the SDA's toxicity to the GBCs.

Foliar application of zinc and selenium regulates cell wall fixation, physiological and gene expression to reduce cadmium accumulation in rice grains.

Zinc (Zn) and selenium (Se) are beneficial elements for crops, enhancing crop quality and alleviating heavy metal toxicity. However, there is limited research on the role of foliar Zn and Se in the mechanism of reducing cadmium (Cd) uptake in crops. A field experiment was conducted to investigate the effect on subcellular distribution, leaf antioxidant enzyme activities, and the transcriptional regulation in the process of Cd accumulation of rice grains after foliar applications of Zn, Se, and their mixed solutions (ZnSe).

MIKC*-type MADS transcription factors control JINGUBANG expression and the degree of pollen dormancy in Arabidopsis.

While pollen dormancy has been proposed to play a necessary role in sexual reproduction, it remains poorly understood. Here, we used traditional pollen germination assays to characterize dormancy. Our results underscore variation in the degree of dormancy between individual pollen grains.

Thymidine phosphorylase mediates SARS-CoV-2 spike protein enhanced thrombosis in K18-hACE2 mice.

Introduction: Thymidine phosphorylase (TYMP), which facilitates platelet activation and thrombosis, is significantly increased in COVID-19 patients. We hypothesize that TYMP mediates SARS-CoV-2 spike protein (SP)-induced thrombosis.

Materials And Methods: Plasmids encoding wildtype SP or empty vector (p3.

Self-Nanoemulsifying Drug Delivery System of Morin: A New Approach for Combating Acute Alcohol Intoxication.

Purpose: Acute alcohol intoxication (AAI) is a life-threatening medical condition resulting from excessive alcohol consumption. Our research revealed the potential of morin (MOR) in treating AAI. However, MOR's effectiveness against AAI was hindered by its poor solubility in water and low bioavailability.

Asthma identified as a major risk factor for recurrent respiratory tract infections in children: a meta-analysis of 29 studies.

Background: Recurrent respiratory tract infections (RRTIs) in children represent a significant clinical challenge. Although some studies have identified potential risk factors, a comprehensive and systematic overview is lacking.

Objective: This analysis is carried out to provide more advanced evidence to guide future prevention and health care.

Suture Bridge Fixation in Treating Traumatic Femoral Osteochondral Injuries in Adults: A Case Study and Review of the Literature.

Achieving anatomic reduction, securing fixation, and ensuring adequate compression are crucial steps in the internal fixation process for traumatic osteochondral defects. A variety of fixation methodologies have been in use, e.g.