Structured training on gross motor skills and physical fitness in 4-5-year-old children.

Objective: Preschool children are in a period of rapid physical development, and improving their gross motor skills and physical fitness is quite important for their health. This study aimed to investigate the effectiveness of a structured physical training program in improving Chinese preschool children's gross motor development and physical fitness.

Method: A sample of 80 children aged 4 to 5 from Fujian, China, were randomly assigned to the intervention group ( = 41), which received a 15-week structured physical training, while the control group ( = 39) continued with their daily physical activity.

Application of nirmatrelvir/ritonavir for the treatment of severe COVID-19 in a 3-year-old child.

Introduction: Nirmatrelvir/ritonavir (Paxlovid) is an effective antiviral drug for treating coronavirus disease 2019 (COVID-19) in adults. However, Paxlovid treatment of children, especially those who are under 12 years and with severe underlying diseases, is rare.

Case Report: A three-year-old COVID-19 patient (weighing 14.

Predictive value of residual active histologic lesions on renal flare in lupus nephritis patients with clinical remission.

Background: Renal flare in lupus nephritis (LN) is a crucial contributing factor to poor kidney outcomes. This study aimed at evaluating the predictive value of residual active histologic lesions on renal flare in proliferative LN patients with clinical remission.

Methods: We retrospectively enrolled LN patients with class III/IV ± V (biopsy 1) who had undergone a protocol repeat biopsy (biopsy 2) at 7.

Biofluid biomarkers for Alzheimer's disease: past, present, and future.

Alzheimer's disease (AD) is a gradually progressive neurodegenerative disease with tremendous social and economic burden. Therefore, early and accurate diagnosis is imperative for effective treatment or prevention of the disease. Cerebrospinal fluid and blood biomarkers emerge as favorable diagnostic tools due to their relative accessibility and potential for widespread clinical use.

Long-term Effects of COVID-19 on Sleep Patterns.

To examine the long-term impact of Coronavirus Disease 2019 (COVID-19) on sleep patterns and prevalence of sleep disorders and to increase public health awareness of long COVID. MATERIAL AND Using the centralized Massachusetts General Brigham Research Patient Data Registry (RPDR), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients were surveyed about their sleep patterns before and after the viral infection. Information related to co-morbid conditions and medications was obtained through chart review.

Silk fibroin as a potential candidate for bone tissue engineering applications.

Silk fibroin (SF), a pivotal biomaterial, holds immense promise for diverse applications within the realm of bone tissue engineering. SF is an ideal scaffold material with exceptional biocompatibility, mechanical robustness, biodegradability, and bioactivity. A plethora of investigations have corroborated SF's efficacy in supporting bone tissue repair and regeneration.

Endophytic Bacteria Improve Bio- and Phytoremediation of Heavy Metals.

Currently, the problem of heavy metal pollution in China is becoming increasingly serious, which poses grave threats to the environment and human health. Owing to the non-biodegradability and toxicity of heavy metals, a more sustainable and ecological approach to remediate heavy metal pollution has always been a focus of attention for environmental researchers. In recent years, many scientists have found that phytoremediation aided by endophytes has high potential to remediate heavy metals owing to its low cost, effectiveness, environmental friendliness, and sustainability compared with physical and chemical methods.

Plasma Glutaminyl-Peptide Cyclotransferase Mediates Glucosamine-Metabolism-Driven Protection Against Hypertension: A Mendelian Randomization Study.

Hypertension is one of the major risk factors for morbidity and mortality worldwide. In this study, Mendelian randomization was utilized to investigate how dietary supplement intake can impact hypertension based on circulating plasma metabolite genome-wide association study (GWAS) datasets, protein quantitative trait loci (pQTLs) of plasma proteins, and multiple public summary-level GWAS data. Pathway enrichment analysis combined with the results of inverse variance weighted Mendelian randomization revealed that a lower risk of hypertension was associated with the dietary intake of glucosamine, an anti-inflammatory supplement: odds ratio (OR) (95% CI): 0.

Research progress on the association of insulin resistance with type 2 diabetes mellitus and Alzheimer's disease.

Type 2 diabetes mellitus (T2DM) is a metabolic disorder that is characterized by insulin resistance and hyperglycemia. It is also known to be a risk factor for Alzheimer's disease (AD). Insulin plays a crucial role in regulating the body's metabolism and is responsible for activating the Phosphoinotide-3-Kinase (PI3K)/Protein Kinase B (Akt) signaling pathway.

Transcutaneous electrical acupoint stimulation for preventing postoperative nausea and vomiting after laparoscopic surgery: A meta-analysis.

Background: Postoperative nausea and vomiting (PONV) is a common adverse event after general surgery. This study aimed to examine the effectiveness and safety of transcutaneous electrical acupoint stimulation (TEAS) for the prevention of nausea and vomiting after laparoscopic surgery.

Method: The Cochrane Library, Pubmed, Embase, and Web of Science databases were accessed from inception to 23 January 2024.

The impact of an online sleep education program (sleep 101) on sleep hygiene and sleep behavior in college students.

This study investigates the effects of a sleep education program, "Sleep 101", on sleep hygiene practices, sleep quality, and weekday and weekend sleep behaviors among college students. A total of 338 college students from a midsized public university in the US participated, with 25 completing both the baseline and post-intervention questionnaire. The Sleep Hygiene Index (SHI) and self-reported questions were used to assess sleep behaviors and subjective sleep quality.

Activation of the CCL22/CCR4 causing EMT process remodeling under EZH2-mediated epigenetic regulation in cervical carcinoma.

Cervical cancer (CC) is an important public health problem for women, gene expression patterns which were governed by epigenetic modifications can result in CC, CC-chemokine receptor 4 (CCR4) interacts with C-C-motif ligand 22 (CCL22) is associated with tumor progression or metastasis. A previous study by the present authors revealed the levels of chemokine CCL22 and its receptor CCR4 are increased in CC tissues, nevertheless, the regulatory mechanisms governing its expression remain poorly understood. The present study aimed to investigate the potential role of enhancer of zeste homolog 2 (EZH2)-induced epigenetic activation of CCL22/CCR4 and caused epithelial-to-mesenchymal transition (EMT) remodeling in CC.

Enhanced Photodetection Performance of InBiSe/ReS Polarization-Sensitive Heterostructure Photodetectors.

Individual anisotropic two-dimensional (2D) materials have been widely applied for developing polarization-sensitive photodetectors, but they often suffer from limitations in photoresponsivity, detection range, etc. To overcome these challenges, van der Waals (vdW) heterostructures created by stacking different 2D materials provide a promising solution to enhance the performance of the photoelectronic device. In this work, a novel polarization-sensitive photodetector is developed by leveraging a heterojunction formed by InBiSe and anisotropic ReS nanoflakes.

Effects of olanzapine in the improvement of body weight and appetite in patients with cancer or receiving chemotherapy: a systematic review and meta-analysis.

Objective: We aimed to assess the effects of olanzapine in the improvement of body weight and appetite in patients with cancer or receiving chemotherapy through a systematic review and meta-analysis.

Methods: We searched the following databases from their inception to April 23, 2024: Embase, PubMed, Web of Science, and the Cochrane Library. The mean difference (MD) and risk ratios were used to calculate by random effects models.

Accuracy of Three Commercial Wearable Devices for Sleep Tracking in Healthy Adults.

Sleep tracking by consumers is becoming increasingly prevalent; yet, few studies have evaluated the accuracy of such devices. We sought to evaluate the accuracy of three devices (Oura Ring Gen3, Fitbit Sense 2, and Apple Watch Series 8) compared to the gold standard sleep assessment (polysomnography (PSG)). Thirty-five participants (aged 20-50 years) without a sleep disorder were enrolled in a single-night inpatient study, during which they wore the Oura Ring, Fitbit, and Apple Watch, and were monitored with PSG.

Peer-Driven Intervention for Care Coordination and Adherence Promotion for Obstructive Sleep Apnea: A Randomized, Parallel-Group Clinical Trial.

Rationale: Obstructive sleep apnea (OSA) is a common condition that is usually treated by continuous positive airway pressure (CPAP) therapy, but poor adherence is common and is associated with worse patient outcomes and experiences. Patient satisfaction is increasingly adopted as a quality indicator by healthcare systems.

Objective: We tested the hypothesis that peer-driven intervention effected through interactive voice-response(PDI-IVR) system leads to better patient satisfaction (primary outcome), care-coordination, and CPAP adherence when compared to active-control.

Substance use and help seeking as coping behaviors among parents and unpaid caregivers of adults in the United States during the COVID-19 pandemic.

During the COVID-19 pandemic, caregiving responsibilities may have been associated with increased substance use. To characterize substance use to cope with stress and willingness to seek help among (i) parents, (ii) unpaid caregivers of adults, and (iii) parent-caregivers. Data were analyzed for 10,444 non-probabilistic internet-based survey respondents of the COVID-19 Outbreak Public Evaluation (COPE) initiative (5227 females, 5217 males).

Analysis of clinical application effects of Esketamine combining Sufentanil in labor analgesia and their impacts on postpartum depression.

Objective: To evaluate the clinical effects of Esketamine combining Sufentanil in labor analgesia and their impacts on postpartum depression.

Methods: This was a retrospective study. One hundred and fifty primiparae with spontaneous labor were selected at SSL Central Hospital of Dongguan City from July 10, 2021 to May 10, 2022 as the research objects and randomly divided into two groups (each n=75).

Joint prevention and control, cross-regional governance: An evolutionary game analysis of fiscal environmental protection expenditure strategies.

The ability to form a collaborative governance alliance is crucial to the in-depth promotion of pollution prevention and control. Starting from the perspective of regional development imbalance, this paper uses an evolutionary game model to explore how initial strategy choice, game order, financial and environmental protection expenditure efficiency, and total factor productivity affect the formation and stabilization of the cooperative alliance of "joint prevention and control, cross-regional governance". The study shows that strategic interactions between governments can lead to "cooperative" or "collusive" outcomes and that game order and initial strategy play a key role in the formation of these outcomes.

Effect of madecassic acid on retinal oxidative stress, inflammation and Growth Factors in streptozotocin-induced diabetic rats.

Diabetic retinopathy (DR) is the leading cause of blindness and visual loss in people with diabetes. It has been suggested that the progression of DR is associated with chronic inflammation and oxidative stress. The aim of the present work was to evaluate the ability of the natural compound madecassic acid (MEA) to reverse the negative impact of streptozotocin (STZ) on retinal injury in rats.

Network pharmacology analysis revealed the mechanism and active compounds of jiao tai wan in the treatment of type 2 diabetes mellitus via SRC/PI3K/AKT signaling.

Ethnopharmacological Relevance: Jiao-tai-wan (JTW) is a traditional Chinese herbal prescription, exerts its therapeutic effects on type 2 diabetes mellitus (T2DM). However, its mechanisms and active components remain unclear.

Aim Of The Study: To investigate the therapeutic mechanisms of JTW in treating type 2 diabetes mellitus (T2DM), focusing on identifying active components, their targets, and validating efficacy through SRC/PI3K/AKT signaling pathway modulation in vitro and in vivo.

Responses of transcriptome and metabolome in peanut leaves to dibutyl phthalate during whole growth period.

Introduction: The application of agricultural film mulching technology has significantly contributed to increasing crop yield and income, but the pollution caused by residual film has seriously affected agricultural production and the natural environment. Agricultural film is commonly employed to enhance the yield of peanuts; its use may lead to excessive dibutyl phthalate (DBP) residues in peanut kernels. But, limited investigations have been conducted on the regulatory mechanism of peanut leaves in response to DBP exposure throughout the entire growth period.