High-voltage long-duration pulsed radiofrequency attenuates neuropathic pain in CCI rats by inhibiting Cav2.2 in spinal dorsal horn and dorsal root ganglion.

Inclinicalpractice, high-voltage, long-duration pulsed radiofrequency (HL-PRF) is effective for several types of intractable neuropathic pain (NP), but the mechanisms have not been well explored. Cav2.2 channels could increase neuronal excitability and neurotransmission accompanying NP.

Disentangled representation and cross-modality image translation based unsupervised domain adaptation method for abdominal organ segmentation.

Purpose: Existing medical image segmentation models tend to achieve satisfactory performance when the training and test data are drawn from the same distribution, while they often produce significant performance degradation when used for the evaluation of cross-modality data. To facilitate the deployment of deep learning models in real-world medical scenarios and to mitigate the performance degradation caused by domain shift, we propose an unsupervised cross-modality segmentation framework based on representation disentanglement and image-to-image translation.

Methods: Our approach is based on a multimodal image translation framework, which assumes that the latent space of images can be decomposed into a content space and a style space.

Iridoids and sesquiterpenoids from Valeriana jatamansi and their anti-influenza virus activities.

Twenty-one new iridoids, jatamansidoids A-U (1-12, 21-26, 32, 35 and 36), two new natural ones, jatamansidoids V (37) and W (38), eighteen known ones (13-20, 27-31, 33 and 34), together with three patchoulol-type sesquiterpenoids (39-41), were isolated from the roots and rhizomes of Valeriana jatamansi. Structurally, compounds 1-7 were the first examples of iridoids from V. jatamansi with unique α, β, γ, δ-unsaturated aldehyde fragment between C-11, C-4, C-5, C-9 and C-8; compound 8 was an unprecedented iridoid derivative with a methyl group (Me-10) at C-1, rather than C-8, and its plausible biogenetic pathway was proposed in this paper; compounds 22 and 23 were the first examples of Δ-iridoids simultaneously replaced by oxygen-containing groups at C-3, C-6 and C-7; compound 24 was the first iridoid with both 6,7- and 1,10-epoxy fragments.

Central nervous system regeneration: the roles of glial cells in the potential molecular mechanism underlying remyelination.

Glial cells play crucial roles in brain homeostasis and pathogenesis of central nervous system (CNS) injuries and diseases. However, the roles of these cells and the molecular mechanisms toward regeneration in the CNS have not been fully understood, especially the capacity of them toward demyelinating diseases. Therefore, there are still very limited therapeutic strategies to restore the function of adult CNS in diseases such as multiple sclerosis (MS).

ctPISP: Protein-Protein Interaction Sites Prediction Using Convolution and Transformer With Data Augmentation.

Protein-protein interactions are the basis of many cellular biological processes, such as cellular organization, signal transduction, and immune response. Identifying protein-protein interaction sites is essential for understanding the mechanisms of various biological processes, disease development, and drug design. However, it remains a challenging task to make accurate predictions, as the small amount of training data and severe imbalanced classification reduce the performance of computational methods.

Mo,Fe-codoped metal phosphide nanosheets derived from Prussian blue analogues for efficient overall water splitting.

Designing non-precious electrocatalysts with multiple active centers and durability toward overall water splitting is of great significance for storing renewable energy. This study reports a low-cost Mo, Fe codoped NiCoP electrocatalysts derived from Co-Fe Prussian blue analogue and following phosphorization process. Benefitted from the optimized electronic configuration, hierarchical structure and abundant active sites, the Mo,Fe-NiCoP/NF electrode has shown competitive oxygen evolution reaction (ƞ = 197 mV) and hydrogen evolution reaction performance (ƞ = 99 mV) when the current density is 10 mA cm in 1 M KOH solution.

Can Use of Default Dispensing Quantities in Electronic Medical Record Lower Opioid Prescribing?

Objectives: Leftover opioids can contribute to misuse and abuse. Recommended dosing quantities in the electronic medical record can guide prescribing patterns. We hypothesized that decreasing the default from 30 doses to 12 doses would decrease the overall number of opioids prescribed without increasing second opioid prescriptions or additional health utilization.

Study on the protective effects of danshen-honghua herb pair (DHHP) on myocardial ischaemia/reperfusion injury (MIRI) and potential mechanisms based on apoptosis and mitochondria.

Context: Danshen, the dried root and rhizome of Bunge (Labiatae) and honghua, the dried flower of L. (Compositae) as the herb pair was used to treat cardiovascular diseases (CVD).

Objective: To study the effects of DHHP on MIRI and mechanisms based on apoptosis and mitochondria.

Visible-light-mediated tandem phosphorylation/cyclization for the synthesis of phosphorylated oxindoles.

The visible-light-mediated tandem phosphorylation/cyclization of -arylacrylamides with H-phosphine oxides has been developed for the synthesis of phosphorylated oxindoles. This efficient and facile process was useful for the construction of a C-P bond and triggered the formation of a C-C bond with good compatibility with functional groups undermild reaction conditions.

Plasmonic-Based Biosensor for the Early Diagnosis of Prostate Cancer.

A tapered optical fiber (TOF) plasmonic biosensor was fabricated and used for the sensitive detection of a panel of microRNAs (miRNAs) in human serum obtained from noncancer and prostate cancer (PCa) patients. Oncogenic and tumor suppressor miRNAs , , miR-200b, miR-141, and miR-21 were tested as predictive cancer biomarkers since multianalyte detection minimizes false-positive and false-negative rates and establishes a strong foundation for early PCa diagnosis. The biosensing platform integrates metallic gold triangular nanoprisms (AuTNPs) laminated on the TOF to excite surface plasmon waves in the supporting metallic layer and enhance the evanescent mode of the fiber surface.

Cytochrome P450 epoxygenase-derived EPA and DHA oxylipins 17,18-epoxyeicosatetraenoic acid and 19,20-epoxydocosapentaenoic acid promote BAT thermogenesis and WAT browning through the GPR120-AMPKα signaling pathway.

The mechanisms whereby fish oil rich in EPA and DHA promotes BAT thermogenesis and WAT browning are not fully understood. Thus, this study aimed to investigate the effects of cytochrome P450 (CYP) epoxygenase-derived EPA and DHA oxylipins 17,18-EpETE and 19,20-EpDPE on BAT thermogenesis and WAT browning and explore the underlying mechanism. Stromal vascular cells (SVCs) were subjected to 17,18-EpETE or 19,20-EpDPE treatment and mice were treated with the CYP epoxygenase inhibitor, the thermogenic marker genes were detected and the involvement of GPR120 and AMPKα were assessed.

Assessing customer financial risk perception and attitude in the hotel industry: Exploring the role of protective measures against COVID-19.

The COVID-19 pandemic has lead authorities from many countries to adopt crucial protective measures such as wearing face masks, lockdowns and social distancing. The purpose of the present study was to explore the relationships among the protective measures against virus handled by hotels with financial risk perception, customer attitude, satisfaction and behavioral intention. The study also calculates the mean comparison across the demographic variables of hotel customer satisfaction and behavioral intention.

VEGFB Promotes Myoblasts Proliferation and Differentiation through VEGFR1-PI3K/Akt Signaling Pathway.

It has been demonstrated that vascular endothelial growth factor B (VEGFB) plays a vital role in regulating vascular biological function. However, the role of VEGFB in regulating skeletal muscle cell proliferation and differentiation remains unclear. Thus, this study aimed to investigate the effects of VEGFB on C2C12 myoblast proliferation and differentiation and to explore the underlying mechanism.

Mussel-inspired adhesive gelatin-polyacrylamide hydrogel wound dressing loaded with tetracycline hydrochloride to enhance complete skin regeneration.

Even though the global wound care market size was valued at USD 19.83 billion in 2020, it is still a challenge to develop a hydrogel-based wound dressing with a good mechanical property, adhesiveness and antibacterial property. This study established and validated a mussel-inspired adhesive hydrogel wound dressing with antibacterial activity by dispersing tetracycline hydrochloride into hydrogel based polydopamine, gelatin and polyacrylamide.

Hierarchically Assembling CoFe Prussian Blue Analogue Nanocubes on CoP Nanosheets as Highly Efficient Electrocatalysts for Overall Water Splitting.

Efficient and durable electrocatalysts are highly desirable for overall water splitting. Herein, a facile strategy is demonstrated to rationally construct CoFe Prussian blue analogues (PBA)@CoP cube-on-sheet hierarchical structure by etching reaction with intermediated CoO to form PBA nanocubes. Benefitting from the heterostructured engineering, the as-synthesized CoFe PBA@CoP presents remarkable electrocatalytic performance in 1.

Expression of Cyclin D1 gene in ovarian cancer and effect of silencing its expression on ovarian cancer cells based on the Oncomine database.

We aimed to analyze the expression of Cyclin D1 (CCND1) gene in ovarian cancer and the influence of silencing its expression on ovarian cancer cells based on the Oncomine database. The expression of CCND1 gene in ovarian cancer was analyzed by utilizing the relevant information in different tumors and Oncomine database. The correlation between CCDN1 expression level and prognosis of ovarian cancer was analyzed by the online database Kaplan-Meier (kmplot.

Relationship between sex hormone-binding globulin level and blood glucose in middle-aged and elder males of Uygur ethnic group.

Objective: To investigate the relationship between sex hormone-binding globulin (SHBG) and blood glucose in elder men of Uygur ethnic group.

Methods: A total of 467 males of ugyur ethnic group resident in Urumqi, Tuokesun County, and Turpan were included by cluster sampling, classified by ages and SHBG level, and compared the metabolic index to define the risk factors by regression.

Results: BMI, waist circumference (WC), glycosylated hemoglobin (GH), fasting insulin level (FIL), SHBG, testosterone, free testosteroneindex (FAI), and HOMA-IR were statistically different in different age groups (P<0.

A systematic review and meta-analysis of the benefits of a gluten-free diet and/or casein-free diet for children with autism spectrum disorder.

Context: It has been suggested that a gluten-free and casein-free (GFCF) diet may alleviate the symptoms of autism spectrum disorder (ASD) and facilitate neurodevelopment of children with ASD. Studies to date have been inconclusive.

Objective: This study aimed to evaluate (through quantitative meta-analysis) the efficacy and safety of a GFCF diet for children with ASD.

Clinical Observation of Effects of Prepregnancy Body Mass Index and Weight Gain during Pregnancy on Neonatal Weight and Delivery Outcome.

. The increase of BMI before pregnancy and during pregnancy will lead to hypertensive disorder in pregnancy (HDP) and abnormal glycolipid metabolism, as well as increase the risk of neonatal weight abnormalities and adverse pregnancy outcome. This study retrospectively analyzed the clinical data of 358 women who were admitted to the obstetrics department of our hospital from January 2018 to July 2019.

Metamaterial-inspired optically transparent active dual-band frequency selective surface with independent wideband tunability.

This paper presents an optically transparent active bandstop frequency selective surface (FSS) with wideband tunability of two resonance frequencies using the concept of miniaturized element FSS (MEFSS). The proposed design consists of metallic square loop arrays on a new optically transparent substrate as the top layer, a glass interlayer, and periodic patterns of cross dipoles on the substrate as the bottom layer. Two kinds of resonant elements loaded with varactors and the designed bias networks achieve two independent tunable stopbands.

Second-generation sequencing assistance in the diagnosis of empyema: A case report.

empyema is rare and easy to be misdiagnosed. An 81-year-old male patient showed symptoms with cough, sputum, and fever for 3 days. Community-acquired pneumonia was diagnosed firstly.