MRI-Based Multifunctional Nanoliposomes for Enhanced HCC Therapy and Diagnosis.

The morbidity and mortality rates of hepatocellular carcinoma (HCC) are high and continue to increase. The antitumor effects of single therapies are limited because of tumor heterogeneity and drug resistance, and the lack of real-time monitoring of tumor progression during the treatment process leads to poor therapeutic outcomes. Therefore, novel nanodelivery platforms combining tumor therapy and diagnosis have garnered extensive attention.

N-methyladenosine RNA methylation regulates microplastics-induced cell senescence in the rainbow trout liver.

Microplastics are prevalent in aquatic ecosystems, impacting various forms of aquatic life, including fish. In this study, Rainbow trout (Oncorhynchus mykiss) were exposed to two concentrations of microplastics (0 and 500 μg/L) over a 14-day period, during which a comprehensive analysis was conducted to assess the liver accumulation of microplastics and their effects on oxidative stress, the liver response, and transcriptomics. Our findings indicated that microplastics significantly accumulated in the liver and activated the antioxidant system in fish by enhancing the activity of antioxidant enzymes.

A simply synthesized, silver ions-doped porous gold microparticles-based SERS aptamer sensor for ultrasensitive and broad-range quantitative detection of IL-6.

Background: The multifunctional cytokine interleukin-6 (IL-6) plays a pivotal role in chronic and acute inflammatory responses, underscoring the importance of accurately determining IL-6 levels for early diagnosis, prevention, and treatment of inflammation.

Results: This study developed a versatile and innovative single-particle surface-enhanced Raman spectroscopy (SERS) sensing platform for the precise and sensitive quantification of IL-6 in complex samples using a novel one-pot synthesized, silver ions-doped three-dimensional porous gold microparticles (PGMs) with abundant hot spots for robust SERS enhancement. By rationally designing rich cytosine-Ag-cytosine base pairs between IL-6 aptamers and complementary chains on the PGMs, we harnessed the SERS-enhancing effect to achieve highly sensitive and specific IL-6 quantification within a wide range of 10 to 10 mg/mL and a limit of detection (LOD) of 0.

Fabrication and Performance Regulation of Lightweight Porous Electromagnetic Absorbing Materials via CO Nucleation-Free Foaming of EP.

In this study, CO reacted with a curing agent through nucleophilic addition to form ammonium salts, enabling the stable capture and internal release of CO, which achieved gas-phase nucleation and foaming. Additionally, the introduction of wave-absorbing agents improved the absorption mechanism and promoted uniform foaming. This nucleation-free foaming process relies on the induced growth of gas nuclei and the synergistic effect of the wave-absorbing agents, effectively preventing the uneven foaming issues caused by traditional nucleating agents.

Genome-wide identification and expression patterns of uridine diphosphate (UDP)-glycosyltransferase genes in the brown planthopper, Nilaparvata lugens.

Uridine diphosphate-glycosyltransferases (UGTs) are responsible for glycosylation by combining various small lipophilic molecules with sugars to produce water-soluble glycosides, which are crucial for the metabolism of plant secondary metabolites and detoxification in insects. This study presents a genome-wide analysis of the UGT gene family in the brown planthopper, Nilaparvata lugens, a destructive insect pest of rice in Asia. Based on the similarity to UGT homologs from other organisms, 20 putative NlUGT genes were identified in N.

Indocyanine green highlights the lymphatic drainage pathways, enhancing the effectiveness of radical surgery for mid-low rectal cancer: A non-randomized controlled prospective study.

Background: Fluorescence-guided lymphadenectomy (FLND) using indocyanine green (ICG) has emerged as a promising technique to enhance the accuracy of lymphadenectomy in rectal cancer surgery. Effective lymphadenectomy is crucial for improving prognosis in patients with advanced rectal cancer, but it remains technically challenging and controversial.

Methods: This prospective nonrandomized controlled study was conducted involving 129 patients underwent laparoscopic surgery, and 64 patients assisted by FLND.

A Decoupling Method for Multimode Flexible Capacitive Sensors to Decouple Spatial Forces and Dynamic Humidity.

This paper focuses on a four-capacitor flexible sensor composed of two electrode materials; also, the decoupling method and sensing performance for multimodal sensing of spatial forces and dynamic humidity are described. In previous work, decoupling of multimode sensors is mostly done by monitoring the types of signals, numerical differences of the same signal, and stacking multiple parameter-sensitive materials. This paper mainly uses the different characteristics of the two electrode materials; in the simulation and experiment of humidity, the moisture-sensitive electrode quickly wets from the outside to the inside and expands, and the contact angle quickly decreases from 58.

Synthesis and antimicrobial activity evaluation of pyrazole derivatives containing imidazothiadiazole moiety.

Aim: The purpose of this work was to investigate the antimicrobial activity of pyrazole derivatives (21a - i and 23a - o) synthesized.

Materials & Methods: The pyrazole derivatives were synthesized, molecular docked and tested for their antimicrobial activity, cytotoxicity, and hemolysis rate.

Results: Most of the target compounds showed high selective inhibitory activity against multi-drug resistance compared with other strains.

Eight-week lat pull-down resistance training with joint instability leads to superior pull-up endurance performance and reduced antagonist coactivation in recreationally active male college students.

This study aimed to investigate the effects of an 8-week lat pull-down resistance training program with joint instability on pull-up performance in male college students. Thirty-four healthy recreationally active male college students were randomly assigned to either the joint instability resistance training (IRT) or traditional resistance training (TRT) group. Participants of the TRT and IRT groups performed lat pull-down training on stable and joint instability conditions for 8 weeks, respectively.

PDA/PMMA blend membrane utilized for the selective adsorption and separation of heavy metal ions.

The detrimental effects of heavy metal aqueous pollution are attracting people's attention increasingly. Membrane separation technology plays a pivotal role in the treatment of aqueous pollution due to its low energy consumption and excellent separation effect. Inspired by the strong adhesion of heavy metal ions by the dopamine in mussel protein, we have fabricated the 5%, 10%, 20% and 30% proportion of polydopamine (PDA)/Polymethyl methacrylate (PMMA) blend membranes with dopamine structure by solvent-induced phase conversion.

Key β1-4 galactosylated glycan receptors of SARS-CoV-2 and its inhibitor from the galactosylated glycoproteins of bovine milk.

Introduction: The binding of the spike (S) protein of SARS-CoV-2 to angiotensin-converting enzyme 2 (ACE2) is a critical stage in the process of infection. While previous studies indicated that the S protein and ACE2 are extensively glycosylated, the functions of glycans in their interactions remain uncertain.

Objectives: This study aimed to investigate the glycan receptors of SARS-CoV-2 and evaluate the inhibitory effects of galactosylated glycoproteins derived from bovine milk on the attachment of SARS-CoV-2 pseudovirus.

Whole-brain functional connectivity and structural network properties in stroke patients with hemiplegia.

Objective: This study explored structural and functional alterations in the whole brain of stroke patients with hemiplegia.

Methods: We collected multimodal magnetic resonance images of 24 patients with ischaemic stroke and 16 age-matched controls. Resting-state functional connectivity (FC) for all brain regions was evaluated.

Enhanced phosphorus bioavailability of biochar derived from sewage sludge co-pyrolyzed with K, Ca-rich biomass ash.

Sewage sludge has great potential for phosphorus (P) recovery. However, sewage sludge-derived biochar suffers from low P bioavailability in land application. K, Ca-rich biomass ash was used to co-pyrolyze with sewage sludge to enhance P bioavailability of synthesized biochar.

Long-term copper exposure induced pyroptosis and inflammation of rat spleen through intestinal-splenic axis.

Copper is an essential micro-element in animal growth. Tribasic copper chloride (TBCC), as an important source of animal feed copper, is widely used in agricultural production. Multiple studies have shown that excessive intake of copper can affect the immune function of animals and lead to disease or death.

Economic costs of tobacco-related diseases in Hong Kong in 2021.

Background: Hong Kong has one of the lowest smoking prevalence both within China and among high-income economies. As tobacco use consistently declined over the past decades, we examine whether there are corresponding cost reductions.

Methods: Data were sourced from diverse population-wide datasets including government reports and public hospital records.

Effect of Selenium Nanoparticles on Alternative Splicing of Rainbow Trout Head Kidney under Heat Stress.

Alternative splicing (AS) is an important post-transcriptional regulation, which can expand the functional diversity of gene products and is a mechanism for eukaryotes to cope with abiotic stress. However, there are few studies on AS events in rainbow trout under heat stress. In this study, RNA-Seq data were used to clarify the effect of selenium nanoparticles (SeNPs) on the AS events of rainbow trout head kidney under heat stress.

Research progress in problem-solving nickel-titanium rotary instrument in endodontics.

Root canal therapy is the primary treatment method for pulpal and periapical diseases. Various advanced endodontic instruments for mechanical preparation have been marketed. The emergence of nickel-titanium rotary instruments has greatly improved the efficiency of root canal preparation.

Protective Effects of 17-βE on the Primary Hepatocytes of Rainbow Trout () Under Acute Heat Stress.

The rainbow trout () is a typical cold-water species. However, due to global warming, it has experienced prolonged high-temperature stress. Research indicates that thermotolerance in rainbow trout varies by sex at multiple physiological levels.

Economic costs attributable to modifiable risk factors: an analysis of 24 million urban residents in China.

Background: Estimating the economic burden of modifiable risk factors is crucial for allocating scarce healthcare resources to improve population health. We quantified the economic burden attributable to modifiable risk factors in an urban area of China.

Methods: Our Shanghai Municipal Health Commission dataset covered 2.

Rapid liver graft implantation in canine: A preliminary study.

Background: The current method for liver graft implantation during the anhepatic phase is complex. Therefore, this study aimed to introduce a modified orthotopic liver transplantation (OLT) technique with major vascular reconstruction using cuff technique to simplify the process of liver graft implantation during the anhepatic phase.

Methods: Twenty-four canines were randomly assigned to two groups: the modified orthotopic liver transplantation group (M-OLT,  = 12) and the control group (n = 12).

Shifting agricultural land use and its unintended water consumption in the North China Plain.

Agricultural land use (ALU) critically influences food production and water resource allocation. This study examines the dynamics of ALU in the North China Plain (NCP), a region characterized by intensive agriculture and severe groundwater over-exploitation, focusing on the multidimensional drivers and their implications for water resource management. By employing an elaborate classification scheme based on satellite imagery and extensive first-hand field data, we identified significant shifts in crop patterns.