A novel dicyanoisophorone-based fluorescent probe for rapid detection of acetylcholinesterase in biological systems.

Acetylcholinesterase (AChE) plays a vital role in various neurological diseases including brain disorders, neurotransmission alterations, and cancer. Developing effective methods to image AChE in biological samples is essential for understanding its mechanisms in biosystems. Here, we introduce a novel fluorescent probe CNA, that enables detection of AChE at 520 nm with rapid response time of 60 s and a detection limit of 0.

A xanthene-based fluorescent probe capable of selectively detecting phosgene in living mouse model.

In this study, we introduced a novel fluorescent probe RNP, which demonstrated outstanding sensitivity and specificity for phosgene detection. Upon phosgene exposure, the probe exhibited rapid fluorescence turn-on within a short re-sponse time (6 s). RNP was also effective in both cellular and murine experiments, where fluorescence enhancement was observed in the respiratory tract of mice.

Small-molecule organic electrode materials on carbon-coated aluminum foil for high-performance sodium-ion batteries.

Organic molecular electrode materials are promising candidates in batteries. However, direct application of small molecule materials usually suffers from drastic capacity decay and inefficient utilization of active materials because of their high solubility in organic electrolytes and low electrical conductivity. Herein, a simple strategy is found to address the above issues through coating the small-molecule organic materials on a commercialized carbon-coated aluminum foil (CCAF) as the enhanced electrode.

Highly Selective Pb(II) Adsorption by DTPA-Functionalized Graphene Oxide/Carboxymethyl Cellulose Aerogel.

Graphene oxide (GO) exhibits a strong adsorption capacity for the removal of heavy metal ions from liquids, making it a topic of increasing interest among researchers. However, a significant challenge persists in the preparation of graphene oxide-based adsorbents that possess both high structural stability and excellent adsorption capacity. In this paper, a green and environmentally friendly ternary composite aerogel based on graphene was successfully synthesized.

Divergent Regioselective Csp-H Difluoromethylation of Aromatic Amines Enabled by Nickel Catalysis.

Herein, the first catalytic protocol for nickel-catalyzed or position difluoromethylation of various aromatic amines has been developed with the assistance of a bidentate phosphine ligand, offering an invaluable synthesis means to construct extensive -difluoromethylated products and difluorooxindole derivatives with significant functional fragments. Furthermore, the gram-scale reaction, broad substrate scope, excellent functional-group compatibility, late-stage difluoromethylation of pesticides, and even formal synthesis of HDAC6 inhibitors further demonstrate the usefulness of this method.

C(sp)-H Monoarylation of Methanol Enabled by a Bidentate Auxiliary.

With the assistance of a practical directing group (COAQ), the first catalytic protocol for the palladium-catalyzed C(sp)-H monoarylation of methanol has been developed, offering an invaluable synthesis means to establish extensive derivatives of crucial arylmethanol functional fragments. Furthermore, the gram-scale reaction, broad substrate scope, excellent functional group compatibility, and even the practical synthesis of medicines further demonstrate the usefulness of this strategy.

Nanocomposite Based on Organic Framework-Loading Transition-Metal Co Ion and Cationic Pillar[6]arene and Its Application for Electrochemical Sensing of l-Ascorbic Acid.

In this study, we constructed a highly sensitive and selective electrochemical sensing strategy for l-ascorbic acid (AA) based on a covalent organic framework (COF)-loading non-noble transition metal Co ion and macrocyclic cationic pillar[6]arene (CP6) nanocomposite (CP6-COF-Co). The COF plays a crucial role in anchoring the Co ion according to its crystalline porous and multiple coordination sites and has an outstanding performance for building an electrochemical sensing platform based on a unique two-dimensional structure. Accordingly, the transition-metal Co ion can be successfully anchored on the framework of COF and shows strong catalytic activity for the determination of AA.

Cobalt-Catalyzed C-H Acetoxylation of Phenols with Removable Monodentate Directing Groups: Access to Pyrocatechol Derivatives.

An efficient cobalt-catalyzed C-H acetoxylation of phenols has been developed by using PIDA (phenyliodine diacetate) as a sole acetoxy source to synthesize pyrocatechol derivatives for the first time. The key feature of this method is the use of earth-abundant metal cobalt as the green and inexpensive catalyst for the acetoxylation of C(sp)-H bonds under neutral reaction conditions. Furthermore, the gram-scale reaction and late-stage functionalization demonstrated the usefulness of this method.

Copper-Catalyzed Coupling of Sulfonamides with Alkylamines: Synthesis of ()--Sulfonylformamidines.

Herein, we describe an efficient copper-catalyzed coupling of sulfonamides with alkylamines to synthesize ()--sulfonylformamidines. The reaction is accomplished under mild conditions without the use of a corrosive acid or base as an additive. It tolerates a broad scope of substrates and generates the products with exclusive ()-stereoselectivity.

The synthesis of water-soluble phosphate pillar[5]arenes functionalized graphene as a fluorescent probe for sensitive detection of paraquat.

We describe a selective and sensitive fluorescence platform for the detection of paraquat (PQ) based on competitive host-guest recognition between phosphate pillar[5]arenes (PWP5) and probe (Safranine T, ST) with using PWP5 functionalized reduced graphene (PWP5-rGO) as the receptor. PQ is a positive charge molecule that is captured by PWP5 via electrostatic interactions. The host-guest interaction between PWP5 and PQ is studied by H NMR.

Intermolecular Amination of Unactivated C(sp )-H Bonds with Cyclic Alkylamines: Formation of C(sp )-N Bonds through Copper/Oxygen-Mediated C(sp )-H/N-H Activation.

The first example of intermolecular amination of unactivated C(sp )-H bonds by cyclic alkylamines mediated by Cu(OAc) /O is reported. This method avoids the use of benzoyloxyamines as the aminating reagent, which are normally prepared from alkylamines in extra steps. A variety of unnatural β -amino acid analogues are synthesized by this simple and efficient procedure.

Pd(II) -Catalyzed Intermolecular Amination of Unactivated C(sp(3) )-H Bonds.

Pd(II) -catalyzed intermolecular amination of unactivated C(sp(3) )-H bonds has been successfully developed for the first time. This method provides a new way to achieve the challenging intermolecular amination of unactivated C(sp(3) )-H bonds, producing a variety of unnatural β(2) -amino carboxylic acid analogues. This C(sp(3) )-H amination protocol is demonstrated with a broad substrate scope, good functional-group tolerance, and chemoselectivity.

Palladium-catalyzed arylation of (di)azinyl aldoxime ethers by aryl iodides: stereoselective synthesis of unsymmetrical (E)-(di)azinylaryl ketoxime ethers.

The first example of direct arylation of (di)azinyl aldoxime ethers by aryl iodides is reported. The reaction produces, in a single step, a variety of geometrically pure unsymmetrical (E)-(di)azinylaryl ketoxime ethers, a class of nitrogenated motifs that have found wide applications in medicinal and organic chemistry but are difficult to access using conventional procedure. The utility of the method is further illustrated in a formal synthesis of the Merck melanin-concentrating hormone 1 receptor antagonist.

Palladium-catalyzed Cs2CO3-promoted arylation of unactivated C(sp(3))-H bonds by (diacetoxyiodo)arenes: shifting the reactivity of (diacetoxyiodo)arenes from acetoxylation to arylation.

PdCl2(CH3CN)2-catalyzed arylation of unactivated C(sp(3))-H bonds using (diacetoxyiodo)arenes as arylation reagents is reported. The reactivity of (diacetoxyiodo)arenes as arylation reagents is enabled in the presence of Cs2CO3 under the reaction conditions. This arylation method is highly efficient and occurs without the use of silver salt.

Arylations of substituted enamides by aryl iodides: regio- and stereoselective synthesis of (Z)-β-amido-β-arylacrylates.

Arylations of substituted enamides by aryl iodides were achieved for the first time via an unusual PdCl2(COD)/Ag3PO4 catalytic system. A broad range of (Z)-β-amido-β-arylacrylates were prepared regio- and stereoselectively in a highly efficient manner.